Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.56 |
| ▸ | HTR3B | O95264 | 1/20 | 0.56 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.56 |
| ▸ | HTR3A | P46098 | 1/20 | 0.56 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.56 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.56 |
| ▸ | CHRM3 | P20309 | 9/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4917429 | 1.00 | HTR3E (0.56) | HTR3EHTR3BCHRNA7HTR3AHTR3D | |
| SCHEMBL5450057 | 0.84 | ALDH1A1 (0.46) | KCNH2 | |
| SCHEMBL5450061 | 0.84 | ALDH1A1 (0.46) | KCNH2 | |
| SCHEMBL3779323 | 0.81 | CHRM3 (0.49) | HTR3EHTR3BCHRNA7HTR3AHTR3D | |
| SCHEMBL13134299 | 0.81 | CHRM3 (0.49) | HTR3EHTR3BCHRNA7HTR3AHTR3D | |
| SCHEMBL3521922 | 0.80 | CHRM3 (0.48) | HTR3EHTR3BCHRNA7HTR3AHTR3D | |
| SCHEMBL14410809 | 0.78 | CHRM1 (0.52) | CHRM3CHRM2CHRM1 | |
| SCHEMBL7000310 | 0.78 | OPRM1 (0.56) | HTR3EHTR3BCHRNA7HTR3AHTR3D | |
| SCHEMBL3783317 | 0.77 | CHRM3 (0.46) | HTR3EHTR3BCHRNA7HTR3AHTR3D | |
| SCHEMBL2632406 | 0.77 | MAPT (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080275079-A1 | 3-Endo)-3-[2,2-Bis-(3-hydroxy-phenyl)-ethenyl]-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane bromide; chronic obstructive lung disease, chronic bronchitis, asthma, chronic respiratory obstruction, pulmonary fibrosis, pulmonary emphysema, allergic rhinitis | GLAXO GROUP LIMITED | 2008-11-06 | — | — | US | disclosed |
| US-20080234315-A1 | M3 Muscarinic Acetylcholine Receptor Antagonists | GLAXO GROUP LIMITED (GB) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234315-A1 | M3 Muscarinic Acetylcholine Receptor Antagonists | CHRM3, CHRM2, CHRM1 | HTR3E 238/4885HTR3B 135/4885CHRNA7 10/4885 |
| US-20080275079-A1 | 3-Endo)-3-[2,2-Bis-(3-hydroxy-phenyl)-ethenyl]-8,8-dimethyl-8-azonia-bicyclo[3.2.1]octane bromide; chronic obstructive lung disease, chronic bronchitis, asthma, chronic respiratory obstruction, pulmonary fibrosis, pulmonary emphysema, allergic rhinitis | CHRM3, EDNRB, BDKRB2 | HTR3E 202/4885HTR3B 63/4885CHRNA7 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.