Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | PDE4A | P27815 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | CCR3 | P51677 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4922456 | 0.93 | ALDH1A1 (0.50) | MEN1KMT2ANR1H4MCHR1SMN1; SMN2 | |
| SCHEMBL4915799 | 0.92 | L3MBTL1 (0.50) | TSHRCCR3CHRM3MEN1KMT2A | |
| SCHEMBL4918023 | 0.86 | TSHR (0.57) | TSHRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4918016 | 0.86 | CCR3 (0.66) | TSHRCCR3MCHR1DRD4SMN1; SMN2 | |
| SCHEMBL4922789 | 0.86 | TSHR (0.60) | TSHRCCR3MEN1NPC1EPHX2 | |
| SCHEMBL4917794 | 0.83 | LMNA (0.52) | TSHRMEN1KMT2AL3MBTL1ACKR3 | |
| SCHEMBL4923485 | 0.83 | ALDH1A1 (0.59) | TSHRMEN1KMT2AACKR3SMN1; SMN2 | |
| SCHEMBL4920802 | 0.83 | SMN1; SMN2 (0.51) | TSHRMEN1KMT2ANR1H4SMN1; SMN2 | |
| SCHEMBL4922766 | 0.81 | TSHR (0.49) | TSHRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14198792 | 0.81 | HTR2A (0.53) | TSHRPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080081824-A1 | Substituted piperidines as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB COMPANY | 2008-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080081824-A1 | Substituted piperidines as modulators of chemokine receptor activity | CCR1, CCR3, CCR2 | TSHR 727/4885PDE4A 323/4885PDE4B 441/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.