Sugi Predict

Sugi Predict / Compounds / SCHEMBL4924726

SCHEMBL4924726

SCHEMBL4924726

CC(C)(C)C[PH](=O)c1ccccc1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 2/20 0.34
▸ MAPT P10636 2/20 0.34
▸ HPGD P15428 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ CYP2C19 P33261 2/20 0.33
▸ HIF1A Q16665 1/20 0.33
▸ RIPK1 Q13546 2/20 0.32
▸ POLB P06746 1/20 0.32
▸ TAAR1 Q96RJ0 2/20 0.32
▸ SLC6A2 P23975 1/20 0.32
▸ CYP3A4 P08684 2/20 0.31
▸ TSHR P16473 2/20 0.31
▸ CYP2D6 P10635 2/20 0.31
▸ CYP1A2 P05177 1/20 0.31
▸ PRMT1 Q99873 1/20 0.31
▸ KMT2A Q03164 3/20 0.31
▸ MEN1 O00255 2/20 0.31
▸ CYP2C9 P11712 1/20 0.31
▸ SMN1; SMN2 Q16637 1/20 0.31
▸ ALDH1A1 P00352 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2155213 0.73 TP53 (0.38) MAPTTSHRKMT2AMEN1SMN1; SMN2
SCHEMBL27499988 0.72 RIPK1 (0.34) MAPTRIPK1
SCHEMBL5572993 0.70 TP53 (0.35) HPGDTSHRKMT2AMEN1SMN1; SMN2
SCHEMBL27769844 0.69 LOXL2 (0.38) CYP2C19TAAR1CYP3A4CYP1A2CYP2C9
SCHEMBL4867131 0.69 MAOB (0.31) GAAMAPTALDH1A1LMNA
SCHEMBL1683358 0.69 MAPK1 (0.33) MAPTCYP2C19HIF1ATAAR1SLC6A2
SCHEMBL4919937 0.68 KMT2A (0.39) RAB9ACYP2C19HIF1APOLBCYP3A4
SCHEMBL13240563 0.68 TP53 (0.33) TSHRALDH1A1
SCHEMBL20377374 0.68 ALDH1A1 (0.33) MAPTHPGDTAAR1SLC6A2TSHR
SCHEMBL6320647 0.68 ALDH1A1 (0.39) MAPTTAAR1TSHRKMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200407381-A1 C-BULKY P-CHIROGENIC ORGANOPHOSPHORUS COMPOUNDS Université de Bourgogne (FR) 2020-12-31 — — US disclosed
CN-111868065-A C-sterically hindered P-chirally derived organophosphorus compounds 勃艮第大学 2020-10-30 — — CN disclosed
US-8471067-B2 Stereoselective preparation of P-chiral four-co-ordinated phosphorus compound (o-Tolylphenylmethylphosphine oxide) by reacting chiral alcohol, chiral amine or chiral thiol, with P-chiral three-co-ordinated phosphorus compound, in presence of electrophile UNIVERSITY COLLEGE DUBLIN (IE) 2013-06-25 — — US disclosed
US-20080255391-A1 Chiral Phosphorus Compounds UNIVERSITY COLLEGE DUBLIN NATIONAL UNIVERSITY OF IRELAND (IE) 2008-10-16 — — US disclosed
EP-1751170-A1 CHIRAL PHOSPHORUS COMPOUNDS UNIVERSITY COLLEGE DUBLIN (IE) 2007-02-14 — — EP disclosed
WO-2005118603-A1 CHIRAL PHOSPHORUS COMPOUNDS UNIVERSITY COLLEGE DUBLIN (IE) 2005-12-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200407381-A1 C-BULKY P-CHIROGENIC ORGANOPHOSPHORUS COMPOUNDS PLCG1, PLCG2, ACHE GAA 2288/4885MAPT 3773/4885HPGD 4182/4885
US-20080255391-A1 Chiral Phosphorus Compounds PHOSPHO1, PNKP, PTMS GAA 4726/4885MAPT 2418/4885HPGD 3300/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.