Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isopropylamine SCHEMBL4837081 | 0.89 | PTPN1 (0.42) | PTPN1ALDH1A1MMP1MMP2MMP9 | |
| Isopropylamine SCHEMBL4791624 | 0.86 | PTGS2 (0.48) | PTPN1ALDH1A1PTGER1PTGS2DPP4 | |
| SCHEMBL4722400 | 0.85 | TLR7 (0.42) | ALDH1A1PTGS2MAPK14CSNK1DMAPK9 | |
| Isopropylamine SCHEMBL4826689 | 0.85 | PTPN1 (0.39) | PTPN1ALDH1A1PTGER1DPP4MAPK14 | |
| SCHEMBL4719075 | 0.82 | MMP13 (0.47) | ALDH1A1MMP1MMP13PTGS2 | |
| SCHEMBL4722407 | 0.81 | NPC1 (0.46) | PTGS2MAPK14TLR7 | |
| SCHEMBL4762794 | 0.80 | ALDH1A1 (0.51) | PTPN1ALDH1A1PTGER1PTGS2MAPK14 | |
| Isopropylamine SCHEMBL4791416 | 0.77 | LMNA (0.39) | PTPN1ALDH1A1PTGER1DPP4MAPK14 | |
| SCHEMBL6004885 | 0.75 | TLR7 (0.41) | ALDH1A1MAPK14CSNK1DMAPK9MAPK10 | |
| Isopropylamine SCHEMBL4790748 | 0.75 | ALDH1A1 (0.43) | PTPN1ALDH1A1MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871770-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | Kalypsys, Inc. (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006116355-A1 | ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS | KALYPSYS, INC. (US) | 2006-11-02 | — | — | WO | disclosed |