Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9342917 | 1.00 | ALDH1A1 (0.49) | ALDH1A1CYP3A4SRCCYP2D6LMNA | |
| SCHEMBL19179659 | 0.86 | SRC (0.48) | ALDH1A1CYP3A4SRCCYP2D6LMNA | |
| SCHEMBL2485143 | 0.85 | KMT2A (0.58) | ALDH1A1CYP3A4LMNAKMT2A | |
| SCHEMBL2488220 | 0.85 | KMT2A (0.58) | ALDH1A1CYP3A4LMNAKMT2A | |
| SCHEMBL31292166 | 0.85 | ALDH1A1 (0.46) | ALDH1A1CYP3A4SRCCYP2D6LMNA | |
| SCHEMBL16446497 | 0.85 | ALDH1A1 (0.46) | ALDH1A1CYP3A4SRCCYP2D6LMNA | |
| SCHEMBL17485220 | 0.84 | SRC (0.52) | ALDH1A1CYP3A4SRCCYP2D6LMNA | |
| SCHEMBL19179660 | 0.84 | SRC (0.52) | ALDH1A1CYP3A4SRCCYP2D6LMNA | |
| SCHEMBL384247 | 0.83 | ALDH1A1 (0.67) | ALDH1A1CYP3A4LMNAKMT2A | |
| SCHEMBL7638229 | 0.83 | PPARA (0.46) | ALDH1A1CYP3A4SRCCYP2D6PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 114 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4317920-A | ANTIRHEUMATIC AGENTS, ANTIINFLAMMATORY AGENTS | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1982-03-02 | — | — | US | claimed |
| CN-100519528-C | Compounds with analgesic effect | ASTRA PHARMACEUTICALS INC (CA) | 2009-07-29 | — | — | CN | disclosed |
| US-20080176903-A1 | Novel Compounds with Analgesic Effect | ASTRAZENECA CANADA INC. (CA) | 2008-07-24 | — | — | US | disclosed |
| US-7312336-B2 | Compounds with analgesic effect | ASTRAZENECA CANADA INC. (CA) | 2007-12-25 | — | — | US | disclosed |
| US-20070088032-A1 | Processes for the Preparation of Benzoimidazole Derivatives | TOM NORMA J | 2007-04-19 | — | — | US | disclosed |
| EP-1660008-A2 | THERAPEUTIC USE OF G53135-05(FGF-20) IN RADIATION PROTECTION | Curagen Corporation (US) | 2006-05-31 | — | — | EP | disclosed |
| EP-1626696-A2 | NOVEL FIBROBLAST GROWTH FACTORS AND METHODS OF USE THEREOF | Curagen Corporation (US) | 2006-02-22 | — | — | EP | disclosed |
| US-6974825-B1 | Compounds with analgesic effect | ASTRAZENECA CANADA INC. (CA) | 2005-12-13 | — | — | US | disclosed |
| EP-0920424-B1 | NON-PEPTIDE BOMBESIN RECEPTOR ANTAGONISTS | WARNER LAMBERT CO (US) | 2005-11-30 | — | — | EP | disclosed |
| US-20050256039-A1 | Novel fibroblast growth factors and methods of use thereof | CURAGEN CORP | 2005-11-17 | — | — | US | disclosed |
| US-5264419-A | N-substituted cycloalkyl and polycycloalkyl α-substituted TRP derivatives | WARNER-LAMBERT COMPANY (US) | 1993-11-23 | — | — | US | disclosed |
| EP-0546108-A4 | PRO-DRUGS FOR CCK ANTAGONISTS | — | 1993-09-22 | — | — | EP | disclosed |
| EP-0547178-A1 | NOVEL CHOLECYSTOKININ ANTAGONISTS, THEIR PREPARATION AND THERAPEUTIC USE | WARNER-LAMBERT COMPANY (US) | 1993-06-23 | — | — | EP | disclosed |
| EP-0546108-A1 | PRO-DRUGS FOR CCK ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1993-06-16 | — | — | EP | disclosed |
| WO-1992004045-A1 | NOVEL CHOLECYSTOKININ ANTAGONISTS, THEIR PREPARATION AND THERAPEUTIC USE | WARNER-LAMBERT COMPANY (US) | 1992-03-19 | — | — | WO | disclosed |
| WO-1992004038-A1 | PRO-DRUGS FOR CCK ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1992-03-19 | — | — | WO | disclosed |
| WO-1992004320-A1 | N-SUBSTITUTED CYCLOALKYL AND POLYCYCLOALKYL ALPHA-SUBSTITUTED Trp DERIVATIVES | WARNER-LAMBERT COMPANY (US) | 1992-03-19 | — | — | WO | disclosed |
| US-4465855-A | ANTIREUMATIC & ANTIINFLAMMATORIES | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT (HU) | 1984-08-14 | — | — | US | disclosed |
| US-4385004-A | Esters of ortho-allylphenol useful for the preparation of arylacetic acid derivatives | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1983-05-24 | — | — | US | disclosed |
| US-4317920-A | ANTIRHEUMATIC AGENTS, ANTIINFLAMMATORY AGENTS | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1982-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070088032-A1 | Processes for the Preparation of Benzoimidazole Derivatives | CCNI, CCNT1, CCNE1 | ALDH1A1 292/4885CYP3A4 63/4885SRC 2134/4885 |
| US-20080176903-A1 | Novel Compounds with Analgesic Effect | OPRL1, OPRK1, OPRM1 | ALDH1A1 656/4885CYP3A4 1186/4885SRC 3309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.