Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 7/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.45 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PLG | P00747 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4284689 | 0.86 | ADRA1A (0.54) | HRH3MBTD1L3MBTL3ALDH1A1HPGD | |
| SCHEMBL4293818 | 0.86 | ADRA1A (0.54) | HRH3MBTD1L3MBTL3ALDH1A1HPGD | |
| SCHEMBL4289248 | 0.83 | L3MBTL3 (0.55) | HRH3MBTD1L3MBTL3CYP3A4F2 | |
| SCHEMBL4288333 | 0.83 | L3MBTL3 (0.55) | HRH3MBTD1L3MBTL3CYP3A4F2 | |
| SCHEMBL4433768 | 0.72 | ADRA1A (0.57) | HRH3MBTD1L3MBTL3ALDH1A1HPGD | |
| SCHEMBL4130774 | 0.71 | ALDH1A1 (0.59) | HRH3MBTD1L3MBTL3ALDH1A1HPGD | |
| SCHEMBL4140037 | 0.71 | ALDH1A1 (0.59) | HRH3MBTD1L3MBTL3ALDH1A1HPGD | |
| SCHEMBL4123429 | 0.71 | ADRA1A (0.64) | HRH3L3MBTL3ALDH1A1HPGDHSD17B10 | |
| SCHEMBL4177089 | 0.70 | HRH3 (0.53) | PROKR1HRH3L3MBTL3 | |
| SCHEMBL22601547 | 0.70 | SMN1; SMN2 (0.55) | PROKR1CNR2ALDH1A1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080247964-A1 | SUBSTITUTED AZASPIRO DERIVATIVES | NEUROGEN CORPORATION | 2008-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080247964-A1 | SUBSTITUTED AZASPIRO DERIVATIVES | HRH3, HRH4, HRH1 | PROKR1 1332/4885HRH3 1/4885MBTD1 2720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.