Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.51 |
| ▸ | PLK1 | P53350 | 1/20 | 0.51 |
| ▸ | CLK1 | P49759 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4923339 | 0.82 | HPGD (0.61) | HPGDALDH1A1KDRCLK1SMN1; SMN2 | |
| SCHEMBL6510754 | 0.81 | ACKR3 (0.52) | HPGDKMT2AHDAC1HDAC6PTGS2 | |
| SCHEMBL4932450 | 0.79 | ROCK1 (0.55) | HPGDKMT2AHDAC1ALDH1A1CSNK2A2 | |
| SCHEMBL4927332 | 0.78 | HPGD (0.65) | HPGDKMT2AHDAC1HDAC6PTGS2 | |
| SCHEMBL425495 | 0.77 | MMP12 (0.58) | HPGDKMT2AHDAC1HDAC6PTGS2 | |
| SCHEMBL11650826 | 0.76 | HPGD (0.55) | HPGDHDAC1HDAC6PTGS2ALDH1A1 | |
| SCHEMBL12272055 | 0.74 | ESRRG (0.46) | HPGDKMT2AHDAC1PTGS2CLK1 | |
| SCHEMBL623403 | 0.74 | SMN1; SMN2 (0.64) | HPGDKMT2AHDAC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL23474257 | 0.74 | CSNK2A2 (0.55) | HPGDKMT2AHDAC1HDAC6ALDH1A1 | |
| SCHEMBL12523457 | 0.73 | MMP13 (0.50) | HPGDHDAC1ALDH1A1CSNK2A2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5369124-A | Fungicides | BAYER AKTIENGESELLSCHAFT (DE) | 1994-11-29 | — | — | US | claimed |
| US-20080293716-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-27 | — | — | US | disclosed |
| US-20080293716-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-27 | — | — | US | disclosed |
| US-20080293716-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-27 | — | — | US | disclosed |
| EP-1708697-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2007-11-28 | — | — | EP | disclosed |
| EP-1708697-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005074642-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293716-A1 | Chemical Compounds | CYP11B2, CYP11B1, REN | HPGD 398/4885KMT2A 4386/4885HDAC1 261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.