Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | GAA | P10253 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | MGAM | O43451 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | SI | P14410 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9463848 | 0.77 | PDE4D (0.60) | CYP1A2CYP1B1ALDH1A1GAALMNA | |
| SCHEMBL5848282 | 0.72 | KDM4E (0.50) | CYP1A2ALDH1A1GAAHPGDLMNA | |
| SCHEMBL19313330 | 0.70 | DPP4 (0.64) | CYP1A2CYP1B1ALDH1A1GAAHPGD | |
| SCHEMBL22135594 | 0.70 | DPP4 (0.56) | CYP1A2CYP1B1ALDH1A1GAAHPGD | |
| SCHEMBL19313331 | 0.70 | DPP4 (0.64) | CYP1A2CYP1B1ALDH1A1GAAHPGD | |
| SCHEMBL31573923 | 0.68 | MAOA (0.40) | CYP1A2ALDH1A1GAAHPGDLMNA | |
| SCHEMBL12608757 | 0.68 | ALDH1A1 (0.34) | ALDH1A1HPGDLMNAMAPTKMT2A | |
| SCHEMBL7478427 | 0.67 | MAOA (0.51) | CYP1A2CYP1B1ALDH1A1GAAHPGD | |
| SCHEMBL5546114 | 0.66 | MAOA (0.42) | ALDH1A1KMT2AMEN1MAOB | |
| SCHEMBL14824859 | 0.66 | MAOA (0.39) | ALDH1A1GAAHPGDSMN1; SMN2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194522-A1 | Development of Fluorogenic Substrates For Monoamine Oxidases (Mao-A and Mao-B) | TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE | 2008-08-14 | — | — | US | disclosed |
| US-20080194522-A1 | Development of Fluorogenic Substrates For Monoamine Oxidases (Mao-A and Mao-B) | TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE | 2008-08-14 | — | — | US | disclosed |
| US-20080194522-A1 | Development of Fluorogenic Substrates For Monoamine Oxidases (Mao-A and Mao-B) | TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, THE | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194522-A1 | Development of Fluorogenic Substrates For Monoamine Oxidases (Mao-A and Mao-B) | MAOA, MAOB, COMT | CYP1A2 20/4885CYP1B1 32/4885ALDH1A1 181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.