SCHEMBL4932746

SCHEMBL4932746

O=[N+]([O-])c1ccc(Cl)cc1Nc1ccc(O)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.63
KMT2A Q03164 4/20 0.63
MAPT P10636 4/20 0.63
GAA P10253 3/20 0.63
TDP1 Q9NUW8 3/20 0.63
MAPK1 P28482 3/20 0.63
PKM P14618 2/20 0.63
L3MBTL1 Q9Y468 2/20 0.56
ATM Q13315 2/20 0.50
KDM4E B2RXH2 1/20 0.50
GFER P55789 1/20 0.50
NPC1 O15118 1/20 0.49
RAB9A P51151 1/20 0.49
TLR9 Q9NR96 1/20 0.49
BACE1 P56817 1/20 0.49
TSHR P16473 1/20 0.49
KCNMA1 Q12791 1/20 0.47
MERTK Q12866 1/20 0.47
KDR P35968 1/20 0.46
ALDH1A1 P00352 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4930639 0.91 L3MBTL1 (0.62) MEN1KMT2AMAPTGAATDP1
SCHEMBL10881006 0.88 L3MBTL1 (0.73) MEN1KMT2AMAPTGAATDP1
SCHEMBL2324309 0.85 L3MBTL1 (0.56) MAPTTDP1MAPK1PKML3MBTL1
SCHEMBL2211997 0.85 L3MBTL1 (0.56) MEN1KMT2AMAPTGAATDP1
SCHEMBL3253899 0.84 L3MBTL1 (0.77) MEN1KMT2AMAPTGAATDP1
SCHEMBL31237080 0.84 KMT2A (0.57) MEN1KMT2AMAPTGAATDP1
Hydrochloric Acid SCHEMBL11533078 0.84 MAPK1 (0.57) MEN1KMT2AMAPTGAATDP1
SCHEMBL14656523 0.83 ALDH3A1 (0.58) MEN1KMT2AMAPTGAAMAPK1
SCHEMBL8885999 0.82 MEN1 (0.57) MEN1KMT2AMAPTGAATDP1
SCHEMBL2332567 0.82 L3MBTL1 (0.65) MEN1KMT2AMAPTGAATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080021069-A1 Receptor Function Regulating Agent TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-01-24 US disclosed
US-20080021069-A1 Receptor Function Regulating Agent TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-01-24 US disclosed
US-20080021069-A1 Receptor Function Regulating Agent TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2008-01-24 US disclosed
EP-1810677-A1 RECEPTOR FUNCTION REGULATING AGENT Takeda Pharmaceutical Company Limited (JP) 2007-07-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080021069-A1 Receptor Function Regulating Agent GPR119, INSR, GPR65 MEN1 4097/4885KMT2A 1963/4885MAPT 4574/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.