Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.55 |
| ▸ | CES1 | P23141 | 1/20 | 0.55 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.55 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 8/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.49 |
| ▸ | NPC1 | O15118 | 7/20 | 0.49 |
| ▸ | PKM | P14618 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | F12 | P00748 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL493896 | 0.88 | FAAH (0.56) | FAAHCES1NCEH1DAGLARAB9A | |
| SCHEMBL493279 | 0.81 | FAAH (0.61) | FAAHCES1NCEH1DAGLARAB9A | |
| SCHEMBL2162094 | 0.77 | NPC1 (0.54) | FAAHCES1NCEH1DAGLARAB9A | |
| SCHEMBL493024 | 0.76 | CYP2C19 (0.47) | RAB9ASMN1; SMN2NPC1PKMLMNA | |
| SCHEMBL493192 | 0.75 | NPC1 (0.56) | RAB9ASMN1; SMN2NPC1PKMTP53 | |
| SCHEMBL493604 | 0.74 | SMN1; SMN2 (0.74) | DAGLARAB9ASMN1; SMN2NPC1PKM | |
| SCHEMBL4034138 | 0.74 | NPC1 (0.65) | RAB9ASMN1; SMN2NPC1PKMTP53 | |
| SCHEMBL6384896 | 0.73 | NPC1 (0.63) | RAB9ASMN1; SMN2NPC1PKMTP53 | |
| SCHEMBL3517537 | 0.72 | NPC1 (0.68) | FAAHCES1NCEH1DAGLARAB9A | |
| SCHEMBL12398575 | 0.72 | CES1 (0.73) | FAAHCES1NCEH1DAGLARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106055-B2 | Substituted amide compounds | GRUENENTHAL GMBH (DE) | 2012-01-31 | — | — | US | disclosed |
| US-20080306084-A1 | Substituted Amide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306084-A1 | Substituted Amide Compounds | OPRK1, NAA50, ACMSD | FAAH 6/4885CES1 957/4885NCEH1 2193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.