Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | CHUK | O15111 | 1/20 | 0.52 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.52 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL493495 | 0.84 | KDM4E (0.70) | SMN1; SMN2LMNAKMT2AMAPTHDAC6 | |
| SCHEMBL28816257 | 0.84 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAPKMKMT2ASMPD1 | |
| SCHEMBL4798828 | 0.82 | TPH1 (0.50) | SMN1; SMN2LMNAKMT2AMAPTHDAC4 | |
| SCHEMBL5208706 | 0.82 | LMNA (0.65) | LMNATHRBCHUKTXNRD1NOX4 | |
| SCHEMBL5205641 | 0.82 | LMNA (0.65) | LMNATHRBCHUKTXNRD1NOX4 | |
| SCHEMBL494155 | 0.81 | SMN1; SMN2 (0.69) | SMN1; SMN2LMNAPKMKMT2ASMPD1 | |
| SCHEMBL15491561 | 0.81 | SCN10A (0.62) | LMNAPKMSMPD1MAPTKDM4E | |
| SCHEMBL2889313 | 0.80 | MAPT (0.55) | SMN1; SMN2LMNAKMT2AMAPTTHRB | |
| SCHEMBL1326759 | 0.80 | NR1H4 (0.57) | SMN1; SMN2SMPD1CHUKTXNRD1NOX4 | |
| SCHEMBL28816269 | 0.79 | HTT (0.64) | SMN1; SMN2LMNAPKMKMT2ASMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080306084-A1 | Substituted Amide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-11 | — | — | US | claimed |
| US-8106055-B2 | Substituted amide compounds | GRUENENTHAL GMBH (DE) | 2012-01-31 | — | — | US | disclosed |
| EP-2139851-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-01-06 | — | — | EP | disclosed |
| US-20080306084-A1 | Substituted Amide Compounds | GRUENENTHAL GMBH (DE) | 2008-12-11 | — | — | US | disclosed |
| WO-2008131946-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306084-A1 | Substituted Amide Compounds | OPRK1, NAA50, ACMSD | SMN1; SMN2 1729/4885LMNA 2485/4885PKM 1161/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.