SCHEMBL493839

SCHEMBL493839

Cc1ccc(NC(=O)c2ccc(Cl)cc2)cc1

nearest known ligand 0.81

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 7/20 0.81
NPC1 O15118 5/20 0.81
SMN1; SMN2 Q16637 7/20 0.70
PTGS2 P35354 1/20 0.70
MAPT P10636 4/20 0.68
ENPP3 O14638 1/20 0.68
ENPP1 P22413 1/20 0.68
ENPP2 Q13822 1/20 0.68
TP53 P04637 1/20 0.64
TSHR P16473 1/20 0.64
NFKB1 P19838 1/20 0.64
NFKB2 Q00653 1/20 0.64
RELA Q04206 1/20 0.64
KMT2A Q03164 3/20 0.64
NT5E P21589 1/20 0.64
MAPK1 P28482 1/20 0.64
ALDH1A1 P00352 1/20 0.61
HTT P42858 1/20 0.61
NPSR1 Q6W5P4 1/20 0.61
KCNK3 O14649 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10192061 1.00 RAB9A (0.81) RAB9ANPC1SMN1; SMN2PTGS2MAPT
SCHEMBL14580374 0.90 RAB9A (1.00) RAB9ANPC1SMN1; SMN2MAPTTP53
SCHEMBL15214321 0.90 RAB9A (1.00) RAB9ANPC1SMN1; SMN2MAPTTP53
SCHEMBL611657 0.90 NPC1 (0.76) RAB9ANPC1SMN1; SMN2PTGS2MAPT
SCHEMBL9767723 0.90 NPC1 (0.76) RAB9ANPC1SMN1; SMN2PTGS2MAPT
SCHEMBL10939703 0.90 NPC1 (0.76) RAB9ANPC1SMN1; SMN2PTGS2MAPT
SCHEMBL27181403 0.90 RAB9A (1.00) RAB9ANPC1SMN1; SMN2MAPTTP53
SCHEMBL822378 0.90 RAB9A (1.00) RAB9ANPC1SMN1; SMN2MAPTTP53
SCHEMBL12310125 0.90 RAB9A (1.00) RAB9ANPC1SMN1; SMN2MAPTTP53
SCHEMBL12959541 0.88 KCNK3 (0.64) RAB9ANPC1SMN1; SMN2PTGS2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0751123-B1 Method for producing alkylsulfinylbenzamides SUMITOMO SEIKA CHEMICALS (JP) 2000-05-10 EP claimed
US-5672751-A TREATMENT OF A HALOBENZAMIDE WITH AN ALKANETHIOL IN THE PRESENCE OF A PHASE TRANSFER CATALYST SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1997-09-30 US claimed
EP-0751123-A2 Method for producing alkylsulfinylbenzamides SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1997-01-02 EP claimed
EP-0620122-B1 Thermosensitive recording material NEW OJI PAPER CO LTD (JP) 1996-03-13 EP claimed
US-5446010-A Substrate sheet, thermosensitive colored image forming layer containing colorless dye precursor, binder, color developing agent having sulfonylureido group, aromatic amide sensitizer; storage stability NEW OJI PAPER CO., LTD. (JP) 1995-08-29 US claimed
EP-0657438-A2 Method for producing alkylsulfinylbenzamides and 1,2-benzisothiazol-3-ones SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1995-06-14 EP claimed
EP-0620122-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-10-19 EP claimed
JP-9123597-A None JP disclosed
EP-3822253-A1 METHOD FOR PREPARING PROPANEDINITRILE OXIME ETHER COMPOUND AND INTERMEDIATE COMPOUND Shenyang Sinochem Agrochemicals R&D Co., Ltd. (CN) 2021-05-19 EP disclosed
CN-111302967-A Preparation method of N-aryl amide compound 广东石油化工学院 2020-06-19 CN disclosed
US-9321766-B1 Kinase inhibitors ALLERGAN, INC. (US) 2016-04-26 US disclosed
US-20160096832-A1 KINASE INHIBITORS ALLERGAN, INC. 2016-04-07 US disclosed
US-8106051-B2 4-Chloro-N-(4-tolyl)benzamide; to enhance the serum level of apoAI SHIONOGI & CO., LTD. (JP) 2012-01-31 US disclosed
JP-H09123597-A THERMAL RECORDING MATERIAL RICOH CO LTD 1997-05-13 JP disclosed
EP-0751123-A2 Method for producing alkylsulfinylbenzamides SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1997-01-02 EP disclosed
US-5508416-A HALOGENATING A 2-(ALKYLTHIO)BENZAMIDE, CYCLIZATION TO HETERO RING AND N-S LINKAGE SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1996-04-16 US disclosed
EP-0620122-B1 Thermosensitive recording material NEW OJI PAPER CO LTD (JP) 1996-03-13 EP disclosed
US-5446010-A Substrate sheet, thermosensitive colored image forming layer containing colorless dye precursor, binder, color developing agent having sulfonylureido group, aromatic amide sensitizer; storage stability NEW OJI PAPER CO., LTD. (JP) 1995-08-29 US disclosed
EP-0657438-A2 Method for producing alkylsulfinylbenzamides and 1,2-benzisothiazol-3-ones SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1995-06-14 EP disclosed
EP-0620122-A1 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-10-19 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160096832-A1 KINASE INHIBITORS ABL1, LCK, ERBB2 RAB9A 2799/4885NPC1 4204/4885SMN1; SMN2 4664/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.