Piberaline

Piberaline

SCHEMBL49391

O=C(c1ccccn1)N1CCN(Cc2ccccc2)CC1

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.71
PRKAB2 O43741 2/20 0.70
PRKAG1 P54619 2/20 0.70
PRKAA2 P54646 2/20 0.70
PRKAA1 Q13131 2/20 0.70
PRKAG3 Q9UGI9 2/20 0.70
PRKAG2 Q9UGJ0 2/20 0.70
PRKAB1 Q9Y478 2/20 0.70
ALDH1A1 P00352 4/20 0.61
KDM4E B2RXH2 3/20 0.61
SMN1; SMN2 Q16637 2/20 0.59
TSHR P16473 2/20 0.59
MEN1 O00255 1/20 0.59
LMNA P02545 1/20 0.59
MAPK1 P28482 1/20 0.59
KMT2A Q03164 1/20 0.59
CYP2D6 P10635 1/20 0.59
CHRM2 P08172 1/20 0.59
NPC1 O15118 1/20 0.57
HTT P42858 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12642635 0.91 L3MBTL1 (0.66) L3MBTL1PRKAB2PRKAG1PRKAA2PRKAA1
SCHEMBL7943306 0.84 L3MBTL1 (1.00) L3MBTL1ALDH1A1SMN1; SMN2LMNAHTT
SCHEMBL20353604 0.82 L3MBTL1 (0.76) L3MBTL1ALDH1A1SMN1; SMN2HTT
SCHEMBL519262 0.82 PRKAA2 (1.00) L3MBTL1PRKAB2PRKAG1PRKAA2PRKAA1
Piberaline SCHEMBL6018379 0.82 PRKAB2 (0.50) L3MBTL1PRKAB2PRKAG1PRKAA2PRKAA1
SCHEMBL1461593 0.82 L3MBTL1 (0.86) L3MBTL1ALDH1A1SMN1; SMN2LMNAKMT2A
SCHEMBL15853631 0.81 RORC (0.64) L3MBTL1PRKAB2PRKAG1PRKAA2PRKAA1
SCHEMBL12120399 0.80 L3MBTL1 (0.71) L3MBTL1ALDH1A1SMN1; SMN2HTT
SCHEMBL16797903 0.80 EPHX2 (0.64) L3MBTL1PRKAB2PRKAG1PRKAA2PRKAA1
SCHEMBL7955601 0.80 L3MBTL1 (0.89) L3MBTL1ALDH1A1SMN1; SMN2LMNAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1039 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9016221-B2 Surface topographies for non-toxic bioadhesion control UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) 2015-04-28 US claimed
WO-2012116278-A1 CANNABINOID RECEPTOR MODULATORS ARENA PHARMACEUTICALS, INC. (US) 2012-08-30 WO claimed
US-20100226943-A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL UNIVERSITY OF FLORIDA (US) 2010-09-09 US claimed
CN-101484152-A Therapeutic combination for painful medical conditions SANOL ARZNEI SCHWARZ GMBH (DE) 2009-07-15 CN claimed
EP-2026788-A1 THERAPEUTIC COMBINATION FOR PAINFUL MEDICAL CONDITIONS SCHWARZ PHARMA AG (DE) 2009-02-25 EP claimed
EP-1954244-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY Scidose, Llc (US) 2008-08-13 EP claimed
WO-2007141018-A1 THERAPEUTIC COMBINATION FOR PAINFUL MEDICAL CONDITIONS SCHWARZ PHARMA AG (DE) 2007-12-13 WO claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 US claimed
US-20070043120-A1 Therapeutic combination for painful medical conditions UCB PHARMA GMBH (DE) 2007-02-22 US claimed
US-20070042969-A1 Combination therapy for pain in painful diabetic neuropathy SRZ PROPERTIES, INC. (US) 2007-02-22 US claimed
EP-1725222-A2 METHODS AND COMPOSITIONS FOR TREATING OR PREVENTING PSYCHIATRIC DISORDERS WITH COX-2 INHIBITORS ALONE AND IN COMBINATION WITH ANTIDEPRESSANT AGENTS Pharmacia Corporation (US) 2006-11-29 EP claimed
WO-2005084654-A2 METHODS AND COMPOSITIONS FOR TREATING OR PREVENTING PSYCHIATRIC DISORDERS WITH COX-2 INHIBITORS ALONE AND IN COMBINATION WITH ANTIDEPRESSANT AGENTS PHARMACIA CORPORATION (US) 2005-09-15 WO claimed
CN-1294519-A Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient INPHARMA SA (CH) 2001-05-09 CN claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
WO-2025129358-A1 STABLE FILM FORMULATIONS FOR HIGH LOADING OF LOW MELTING POINT ACTIVES INTELGENX CORP. (CA) 2025-06-26 WO disclosed
US-12109219-B2 Cannabinoid receptor modulators ARENA PHARMACEUTICALS, INC. (US) 2024-10-08 US disclosed
WO-1995018603-A1 TRANSDERMAL DEVICE CONTAINING POLYVINYLPYRROLIDONE AS SOLUBILITY ENHANCER NOVEN PHARMACEUTICALS, INC. (US) 1995-07-13 WO disclosed
US-4647599-A Sustained release pharmaceutical tablets and process for the preparation thereof EGYT GYOGYSZERVEGYESZETI CYAR (HU) 1987-03-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070042969-A1 Combination therapy for pain in painful diabetic neuropathy GRIN2B, GRIN2A, GRIN3A L3MBTL1 2787/4885PRKAB2 2398/4885PRKAG1 2754/4885
US-20070043120-A1 Therapeutic combination for painful medical conditions PDE1B, CA2, CACNA1S L3MBTL1 2100/4885PRKAB2 3245/4885PRKAG1 3817/4885
US-12109219-B2 Cannabinoid receptor modulators CNR1, CNR2, GPR18 L3MBTL1 4843/4885PRKAB2 1332/4885PRKAG1 943/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.