Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4946248 | 1.00 | PIK3R1 (0.37) | PIK3R1PIK3CAPLA2G2AALDH1A1MAPT | |
| SCHEMBL4946256 | 1.00 | PIK3R1 (0.37) | PIK3R1PIK3CAPLA2G2AALDH1A1MAPT | |
| SCHEMBL13993110 | 0.94 | PLA2G2A (0.37) | PIK3R1PIK3CAPLA2G2AALDH1A1MAPT | |
| SCHEMBL4946209 | 0.78 | PLA2G2A (0.47) | PIK3R1PIK3CAPLA2G2A | |
| SCHEMBL4948035 | 0.73 | MAPT (0.52) | PIK3R1PIK3CAPLA2G2AMAPT | |
| SCHEMBL4949031 | 0.67 | PIK3R1 (0.48) | PIK3R1PIK3CAPLA2G2AALDH1A1MAPT | |
| SCHEMBL4949024 | 0.67 | PIK3R1 (0.48) | PIK3R1PIK3CAPLA2G2AALDH1A1MAPT | |
| SCHEMBL13993109 | 0.65 | PIK3R1 (0.47) | PIK3R1PIK3CAPLA2G2AALDH1A1MAPT | |
| SCHEMBL28561012 | 0.64 | LMNA (0.43) | ALDH1A1MAPTKDM4EGAAMEN1 | |
| SCHEMBL6306900 | 0.62 | CCR2 (0.71) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2003129-A1 | 1H-Pyrido[3,4-B]indol-1-one and 2,3,4,9-Tetrahydro-1H-Beta-Carbolin-1-one Derivatives | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | disclosed |