SCHEMBL4948256

SCHEMBL4948256

Cc1ccc(S(=O)(=O)NC(Cc2ccccc2)C(=O)C(Cl)C=O)cc1

nearest known ligand 0.57

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ MMP9 P14780 9/20 0.57
▸ TDP1 Q9NUW8 1/20 0.56
▸ MMP2 P08253 9/20 0.55
▸ ADAMTS4 O75173 1/20 0.55
▸ CA2 P00918 1/20 0.55
▸ CA7 P43166 1/20 0.55
▸ CTSL P07711 1/20 0.53
▸ ALDH1A1 P00352 2/20 0.53
▸ ADAMTS5 Q9UNA0 1/20 0.53
▸ MAPT P10636 1/20 0.53
▸ POLB P06746 1/20 0.53
▸ GAA P10253 1/20 0.50
▸ MMP1 P03956 1/20 0.50
▸ MMP3 P08254 1/20 0.50
▸ MMP7 P09237 1/20 0.50
▸ MMP13 P45452 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2926667 1.00 MMP9 (0.57) MMP9TDP1MMP2ADAMTS4CA2
SCHEMBL8018411 0.88 MMP9 (0.61) MMP9TDP1MMP2ADAMTS4CA2
SCHEMBL617758 0.87 MMP9 (0.60) MMP9TDP1MMP2ADAMTS4CA2
SCHEMBL5481551 0.87 MMP9 (0.60) MMP9TDP1MMP2ADAMTS4CA2
SCHEMBL433896 0.85 MMP9 (0.67) MMP9TDP1MMP2ADAMTS4CA2
SCHEMBL561566 0.85 MMP9 (0.67) MMP9TDP1MMP2ADAMTS4CA2
SCHEMBL29961332 0.84 MMP9 (0.63) MMP9TDP1MMP2ADAMTS4CA2
SCHEMBL15213296 0.84 MMP9 (0.63) MMP9TDP1MMP2ADAMTS4CA2
SCHEMBL14519991 0.84 MMP9 (0.63) MMP9TDP1MMP2ADAMTS4CA2
SCHEMBL6331296 0.83 MMP9 (0.61) MMP9TDP1MMP2ADAMTS4CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103221069-A Alumina nanoparticle bioconjugates and methods of stimulating an immune response using said bioconjugates PROVIDENCE HEALTH & SERVICES OREGON 2013-07-24 — — CN disclosed
EP-1066315-B1 USE OF INHIBITORS OF MAMMALIAN ASPARAGINYL ENDOPEPTIDASE FOR MODULATING THE IMMUNE SYSTEM UNIV DUNDEE (GB) 2008-05-28 — — EP disclosed
US-20070269832-A1 Novel affinity labels IMMUNOCHEMISTRY TECHNOLOGIES, LLC 2007-11-22 — — US disclosed
US-20060286091-A1 RelA-ASSOCIATED INHIBITOR, PROCESS FOR PRODUCING THE SAME AND UTILIZATION THEREOF CITY OF NAGOYA (JP) 2006-12-21 — — US disclosed
US-7119169-B2 RelA-associated inhibitor, process for producing the same and utilization thereof CITY OF NAGOYA (JP) 2006-10-10 — — US disclosed
US-20060148023-A1 Affinity labeling of serine proteases for simultaneous detection of multiple serine protease activity levels IMMUNOCHEMISTRY TECHNOLOGIES, LLC 2006-07-06 — — US disclosed
US-20050136492-A1 Affinity labeling of enzymes for detection of enzyme activity level in living cells IMMUNOCHEMISTRY TECHNOLOGIES, LLC 2005-06-23 — — US disclosed
US-20030148396-A1 RelA-associated inhibitor, process for producing the same and utilization thereof ONO PHARMACEUTICAL CO., LTD. 2003-08-07 — — US disclosed
WO-2003060466-A2 AFFINITY LABELING OF SERINE PROTEASES FOR SIMULTANEOUS DETECTION OF MULTIPLE SERINE PROTEASE ACTIVITY LEVELS IMMUNOCHEMISTRY TECHNOLOGIES, LLC (US) 2003-07-24 — — WO disclosed
WO-2003059877-A2 NOVEL AFFINITY LABELS IMMUNOCHEMISTRY TECHNOLOGIES, LLC (US) 2003-07-24 — — WO disclosed
EP-1066315-A1 USE OF INHIBITORS OF MAMMALIAN ASPARAGINYL ENDOPEPTIDASE FOR THERAPY OF AUTOIMMUNE DISEASE UNIVERSITY OF DUNDEE (GB) 2001-01-10 — — EP disclosed
WO-1999048910-A1 USE OF INHIBITORS OF MAMMALIAN ASPARAGINYL ENDOPEPTIDASE FOR THERAPY OF AUTOIMMUNE DISEASE UNIVERSITY OF DUNDEE (GB) 1999-09-30 — — WO disclosed
US-5762939-A Method for producing influenza hemagglutinin multivalent vaccines using baculovirus MG-PMC, LLC (US) 1998-06-09 — — US disclosed
US-5708148-A MUTANTS OF ESCHERICHIA COLI CELLS, DENATURING POLYPEPTIDES, REFOLDING AND INCUBATION CIBA GEIGY CORPORATION (US) 1998-01-13 — — US disclosed
EP-0434605-B1 Novel process for the production of unfused protein in E. coli CIBA GEIGY AG (CH) 1996-09-11 — — EP disclosed
WO-1995035366-A1 ANIMAL MODEL FOR ALZHEIMER'S DISEASE THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 1995-12-28 — — WO disclosed
EP-0541058-A1 Expression of a mature proteinase 2a, its partial purification and preparation of inhibitory active substrates BOEHRINGER INGELHEIM INTERNATIONAL GmbH (DE) 1993-05-12 — — EP disclosed
WO-1993000926-A1 TREATMENT OF PERIODONTAL DISEASE WITH PROTEASE INHIBITORS CHILDREN'S MEDICAL CENTER CORPORATION (US) 1993-01-21 — — WO disclosed
EP-0434605-A2 Novel process for the production of unfused protein in E. coli CIBA-GEIGY AG (CH) 1991-06-26 — — EP disclosed
US-4906571-A Cell surface modification using a novel glycoproteinase of pasteurella haemolytica UNIVERSITY OF GUELPH (CA) 1990-03-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070269832-A1 Novel affinity labels ANPEP, SLC7A1, DNPEP MMP9 421/4885TDP1 3174/4885MMP2 50/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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