SCHEMBL4949384

SCHEMBL4949384

CCCC[Si](c1ccccc1)(c1ccccc1)[C@@]1(n2cc(C)c(=O)[nH]c2=O)O[C@H](CO)[C@@H](O)[C@H]1O

nearest known ligand 0.39

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
TK2 O00142 7/20 0.39
TK1 P04183 4/20 0.37
RNASE1 P07998 1/20 0.36
TYMP P19971 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7192452 0.91 TK2 (0.35) TK2TK1
SCHEMBL3300455 0.84 RNASE1 (0.37) TK2TK1RNASE1
SCHEMBL5668664 0.82 TK1 (0.39) TK2TK1RNASE1TYMP
SCHEMBL28162665 0.75 RNASE1 (0.41) TK2TK1RNASE1TYMP
SCHEMBL28182722 0.74 TK2 (0.46) TK2TK1
SCHEMBL6851558 0.74 TK1 (0.34) TK2TK1
SCHEMBL28190357 0.73 TK2 (0.47) TK2TK1
SCHEMBL8744222 0.73 TK2 (0.41) TK2TK1
SCHEMBL3300461 0.73 TK2 (0.38) TK2TK1RNASE1TYMP
SCHEMBL8053437 0.72 TK1 (0.42) TK2TK1TYMP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 368 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2003520042-A 2003-07-02 JP claimed
EP-1250157-A1 ANTISENSE MODULATION OF INDUCIBLE NITRIC OXIDE SYNTHASE EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2002-10-23 EP claimed
WO-2001052902-A1 ANTISENSE MODULATION OF INDUCIBLE NITRIC OXIDE SYNTHASE EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2001-07-26 WO claimed
EP-1631235-A4 COMPOSITIONS AND METHODS FOR THE MODULATION OF THE EXPRESSION OF B7 PROTEIN ISIS PHARMACEUTICALS INC (US) 2008-05-21 EP disclosed
EP-1631659-A4 MODULATION OF THE RNA INTERFERENCE PATHWAY ISIS PHARMACEUTICALS INC (US) 2008-02-13 EP disclosed
EP-1613728-A4 MODULATION OF DIACYLGLYCEROL ACYLTRANSFERASE 1 EXPRESSION ISIS PHARMACEUTICALS INC (US) 2007-07-25 EP disclosed
EP-1718762-A1 ANTISENSE OLIGONUCLEOTIDE MODULATION OF STAT3 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2006-11-08 EP disclosed
EP-1664267-A2 MODULATION OF GROWTH HORMONE RECEPTOR EXPRESSION AND INSULIN-LIKE GROWTH FACTOR EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2006-06-07 EP disclosed
EP-1660682-A2 ANTISENSE MODULATION OF p38 MITOGEN ACTIVATED PROTEIN KINASE EXPRESSION Isis Pharmaceuticals, Inc. (US) 2006-05-31 EP disclosed
EP-1648910-A2 ANTISENSE MODULATION OF STEAROYL-COA DESATURASE EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2006-04-26 EP disclosed
EP-1633302-A2 MODULATION OF APOLIPOPROTEIN (A) EXPRESSION Isis Pharmaceuticals, Inc. (US) 2006-03-15 EP disclosed
WO-2000032818-A1 ANTISENSE MODULATION OF CELLULAR INHIBITOR OF APOPTOSIS-2 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2000-06-08 WO disclosed
WO-2000031296-A1 ANTISENSE MODULATION OF INTERLEUKIN-15 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2000-06-02 WO disclosed
WO-2000031103-A1 ANTISENSE MODULATION OF MEK2 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2000-06-02 WO disclosed
WO-2000031105-A1 ANTISENSE MODULATION OF INHIBITOR-KAPPA B KINASE-BETA EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2000-06-02 WO disclosed
WO-2000030686-A1 ANTISENSE MODULATION OF INHIBITOR-KAPPA B KINASE-ALPHA EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2000-06-02 WO disclosed
WO-2000031111-A1 ANTISENSE MODULATION OF NF-KAPPA-B P65 SUBUNIT EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2000-06-02 WO disclosed
WO-2000031106-A1 ANTISENSE MODULATION OF MEK1 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2000-06-02 WO disclosed
WO-2000008042-A1 AMINOOXY-MODIFIED NUCLEOSIDIC COMPOUNDS AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM ISIS PHARMACEUTICALS, INC. (US) 2000-02-17 WO disclosed
WO-1999049065-A1 ANTISENSE MODULATION OF HUMAN MDM2 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 1999-09-30 WO disclosed