SCHEMBL6851558

SCHEMBL6851558

CCc1cn([C@]2([Si](c3ccccc3)(c3ccccc3)C(C)(C)C)O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]c1=O

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TK1 P04183 3/20 0.34
TK2 O00142 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5668664 0.89 TK1 (0.39) TK1TK2
SCHEMBL8539644 0.86 LMNA (0.37) TK2
SCHEMBL9030188 0.83 P2RY2 (0.41)
SCHEMBL9029503 0.83 P2RY2 (0.41)
SCHEMBL7192452 0.83 TK2 (0.35) TK1TK2
SCHEMBL6468417 0.76 PNP (0.41) TK1
SCHEMBL8004041 0.76 LMNA (0.42)
SCHEMBL9545108 0.74 TK2 (0.40) TK1TK2
SCHEMBL27271553 0.74 TK2 (0.40) TK1TK2
SCHEMBL4949384 0.74 TK2 (0.39) TK1TK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1465905-A2 ANTISENSE MODULATION OF MYD88 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2004-10-13 EP disclosed
EP-1328536-A1 ANTISENSE MODULATION OF GLIOMA-ASSOCIATED ONCOGENE-1 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2003-07-23 EP disclosed
WO-2003049691-A2 ANTISENSE MODULATION OF PCTAIRE PROTEIN KINASE 1 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2003-06-19 WO disclosed
WO-2003046132-A2 ANTISENSE MODULATION OF MYD88 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2003-06-05 WO disclosed
WO-2002020549-A1 ANTISENSE MODULATION OF GLIOMA-ASSOCIATED ONCOGENE-1 EXPRESSION ISIS PHARMACEUTICALS, INC. (US) 2002-03-14 WO disclosed