Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 18/20 | 0.52 |
| ▸ | MMP9 | P14780 | 18/20 | 0.52 |
| ▸ | MMP14 | P50281 | 16/20 | 0.52 |
| ▸ | MMP8 | P22894 | 8/20 | 0.52 |
| ▸ | MMP3 | P08254 | 7/20 | 0.52 |
| ▸ | MMP7 | P09237 | 4/20 | 0.52 |
| ▸ | MMP1 | P03956 | 3/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2381076 | 0.76 | MMP2 (0.69) | MMP2MMP9MMP14MMP8MMP3 | |
| SCHEMBL315578 | 0.75 | MMP2 (0.65) | MMP2MMP9MMP14MMP8MMP3 | |
| SCHEMBL4953626 | 0.74 | PGR (0.42) | MMP1NR3C1PGR | |
| SCHEMBL2381073 | 0.70 | MMP2 (0.78) | MMP2MMP9MMP14MMP8MMP3 | |
| SCHEMBL2684163 | 0.69 | MMP2 (1.00) | MMP2MMP9MMP14MMP8MMP3 | |
| SCHEMBL2380308 | 0.69 | MMP2 (0.76) | MMP2MMP9MMP14MMP8MMP3 | |
| SCHEMBL315716 | 0.69 | MMP2 (1.00) | MMP2MMP9MMP14MMP8MMP3 | |
| SCHEMBL7063318 | 0.66 | TSHR (0.54) | NR3C1PGR | |
| SCHEMBL10238412 | 0.66 | MMP2 (0.56) | MMP2MMP9MMP14MMP8MMP3 | |
| SCHEMBL8719438 | 0.66 | PTGS2 (0.68) | MMP1NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1986657-A2 | METHOD OF TREATING A SUBJECT SUFFERING FROM DEGENERATIVE DISC DISEASE USING A MATRIX METALLOPROTEASE INHIBITOR | Discogen, LLC (US) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007098099-A2 | METHOD OF TREATING A SUBJECT SUFFERING FROM DEGENERATIVE DISC DISEASE USING A MATRIX METALLOPROTEASE INHIBITOR | DISCOGEN, LLC (US) | 2007-08-30 | — | — | WO | disclosed |