Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 3/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MLNR | O43193 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4953617 | 0.74 | MMP2 (0.52) | PGRMMP1NR3C1 | |
| SCHEMBL4294130 | 0.69 | LMNA (0.50) | PGRKMT2ALMNAMMP1SMN1; SMN2 | |
| SCHEMBL8719438 | 0.67 | PTGS2 (0.68) | PGRPTGS1PTGS2KMT2AKDM4E | |
| SCHEMBL315717 | 0.67 | PGR (0.55) | PGRLMNAHPGDMMP1MAPT | |
| SCHEMBL30659708 | 0.64 | KEAP1 (0.55) | PGRPTGS1PTGS2KMT2ATSHR | |
| SCHEMBL8026971 | 0.62 | HTR6 (0.68) | PGRKMT2ATSHRSMN1; SMN2NR3C1 | |
| SCHEMBL7063318 | 0.62 | TSHR (0.54) | PGRKMT2AKDM4ETSHRSMN1; SMN2 | |
| SCHEMBL29904739 | 0.62 | KEAP1 (0.65) | PGRPTGS1PTGS2KMT2AKDM4E | |
| SCHEMBL2068498 | 0.62 | KEAP1 (0.65) | PGRPTGS1PTGS2KMT2AKDM4E | |
| SCHEMBL1127421 | 0.62 | CA2 (0.62) | KEAP1L3MBTL1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1986657-A2 | METHOD OF TREATING A SUBJECT SUFFERING FROM DEGENERATIVE DISC DISEASE USING A MATRIX METALLOPROTEASE INHIBITOR | Discogen, LLC (US) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007098099-A2 | METHOD OF TREATING A SUBJECT SUFFERING FROM DEGENERATIVE DISC DISEASE USING A MATRIX METALLOPROTEASE INHIBITOR | DISCOGEN, LLC (US) | 2007-08-30 | — | — | WO | disclosed |