Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 1/20 | 0.52 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | ATM | Q13315 | 3/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HSD17B3 | P37058 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4956069 | 0.89 | CCR4 (0.49) | CCR4SLC16A3ALDH1A1KDM4EATM | |
| SCHEMBL10879201 | 0.84 | CCR4 (0.50) | CCR4SLC16A3ALDH1A1KDM4EATM | |
| SCHEMBL10881037 | 0.82 | CCR4 (0.62) | CCR4SLC16A3ALDH1A1KDM4EATM | |
| SCHEMBL6888225 | 0.81 | SRC (0.53) | ALDH1A1KDM4EATMGLAGAA | |
| SCHEMBL14111513 | 0.79 | ALDH1A1 (0.47) | CCR4SLC16A3ALDH1A1KDM4EATM | |
| SCHEMBL4958360 | 0.78 | KDM4E (0.62) | CCR4ALDH1A1KDM4EGAAHTT | |
| SCHEMBL21457065 | 0.77 | CCR4 (0.56) | CCR4SLC16A3ALDH1A1KDM4EATM | |
| SCHEMBL1850238 | 0.76 | ALDH1A1 (0.56) | ALDH1A1KDM4EGLAGAAHTT | |
| SCHEMBL17941688 | 0.76 | KDM4E (0.59) | CCR4SLC16A3ALDH1A1KDM4EATM | |
| SCHEMBL5279173 | 0.75 | CCR4 (0.41) | CCR4SLC16A3ALDH1A1KDM4EATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080032917-A1 | FLAVIVIRUS PROTEASE SUBSTRATES AND INHIBITORS | IRM LLC, A DELAWARE LIMITED LIABILITY COMPANY (BM) | 2008-02-07 | — | — | US | claimed |
| WO-2006014232-A2 | DENGUE PROTEASE SUBSTRATES AND INHIBITORS | IRM LLC (BM) | 2006-02-09 | — | — | WO | claimed |
| US-20050222383-A1 | Prostasin substrates and inhibitors | IRM LLC (BM) | 2005-10-06 | — | — | US | claimed |
| WO-2005076886-A2 | PROSTASIN SUBSTRATES AND INHIBITORS | IRM LLC (BM) | 2005-08-25 | — | — | WO | claimed |
| US-20040009911-A1 | Hepsin substrates and prodrugs | IRM, LLC (BM) | 2004-01-15 | — | — | US | claimed |
| WO-2003064620-A2 | HEPSIN SUBSTRATES AND PRODRUGS | IRM, LLC (BM) | 2003-08-07 | — | — | WO | claimed |
| US-20190144912-A1 | METHODS FOR IDENTIFYING NOVEL ANTIBIOTICS AND RELATED COMPOSITIONS | SCRIPPS RESEARCH INST (US) | 2019-05-16 | — | — | US | disclosed |
| EP-3344043-A2 | METHODS FOR IDENTIFYING NOVEL ANTIBIOTICS AND RELATED COMPOSITIONS | The Scripps Research Institute (US) | 2018-07-11 | — | — | EP | disclosed |
| CN-108135181-A | Methods for identifying novel antibiotics and related compositions | 斯克利普斯研究院 | 2018-06-08 | — | — | CN | disclosed |
| WO-2017040762-A2 | METHODS FOR IDENTIFYING NOVEL ANTIBIOTICS AND RELATED COMPOSITIONS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-03-09 | — | — | WO | disclosed |
| US-20040009911-A1 | Hepsin substrates and prodrugs | IRM, LLC (BM) | 2004-01-15 | — | — | US | disclosed |
| WO-2003064620-A2 | HEPSIN SUBSTRATES AND PRODRUGS | IRM, LLC (BM) | 2003-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040009911-A1 | Hepsin substrates and prodrugs | HPN, SPR, TMPRSS15 | CCR4 3203/4885SLC16A3 886/4885ALDH1A1 2407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.