Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 9/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 9/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 9/20 | 0.46 |
| ▸ | AQP1 | P29972 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4962088 | 0.91 | CA2 (0.53) | CA2ADRA1DADRA1AADRA1BAQP1 | |
| SCHEMBL8221067 | 0.86 | POLB (0.57) | CA2ADRA1DADRA1AADRA1BCYP2D6 | |
| SCHEMBL4960741 | 0.84 | CA2 (0.46) | CA2ADRA1DADRA1AADRA1BAQP1 | |
| SCHEMBL6103977 | 0.84 | AQP1 (0.54) | CA2ADRA1DADRA1AADRA1BAQP1 | |
| SCHEMBL14364273 | 0.83 | CA2 (0.49) | CA2ADRA1DADRA1AADRA1BAQP1 | |
| SCHEMBL6104735 | 0.83 | HTR6 (0.44) | CA2ADRA1DADRA1AADRA1BCYP2D6 | |
| SCHEMBL4963942 | 0.83 | CA2 (0.49) | CA2ADRA1DADRA1AADRA1BAQP1 | |
| SCHEMBL4961040 | 0.82 | CA2 (0.43) | CA2ADRA1DADRA1AADRA1BCYP2D6 | |
| SCHEMBL4958758 | 0.81 | CA2 (0.47) | CA2ADRA1DADRA1AADRA1BHTT | |
| SCHEMBL4961831 | 0.81 | ADRA1D (0.47) | CA2ADRA1DADRA1AADRA1BAQP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871759-A1 | BENZODIOXANE AND BENZODIOXOLANE DERIVATIVES AND USES THEREOF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006116158-A1 | BENZODIOXANE AND BENZODIOXOLANE DERIVATIVES AND USES THEREOF | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |
| US-20060241172-A1 | Benzodioxane and benzodioxolane derivatives and uses thereof | WYETH (US) | 2006-10-26 | — | — | US | disclosed |
| US-20060241172-A1 | Benzodioxane and benzodioxolane derivatives and uses thereof | WYETH (US) | 2006-10-26 | — | — | US | disclosed |
| US-20060241172-A1 | Benzodioxane and benzodioxolane derivatives and uses thereof | WYETH (US) | 2006-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241172-A1 | Benzodioxane and benzodioxolane derivatives and uses thereof | HTR2C, HTR1D, HTR1A | CA2 4153/4885ADRA1D 21/4885ADRA1A 37/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.