Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK6 | P43250 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | GLA | P06280 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | CASP7 | P55210 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL634465 | 0.77 | GRK6 (0.50) | GRK6KDM4EALDH1A1GLAHPGD | |
| SCHEMBL28259756 | 0.70 | KDM4E (0.41) | KDM4EALDH1A1GLAHPGDSMN1; SMN2 | |
| SCHEMBL9742367 | 0.69 | KDM4E (0.36) | KDM4EALDH1A1GLAHPGDSMN1; SMN2 | |
| SCHEMBL10469497 | 0.66 | ALDH1A1 (0.39) | KDM4EALDH1A1GLAHPGDSMN1; SMN2 | |
| SCHEMBL5476684 | 0.65 | KDM4E (0.52) | KDM4EALDH1A1GLAHPGDSMN1; SMN2 | |
| SCHEMBL10649168 | 0.65 | KDM4E (0.42) | KDM4EALDH1A1GLAHPGDSMN1; SMN2 | |
| SCHEMBL8112 | 0.63 | GRK6 (1.00) | GRK6KDM4EALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL29778809 | 0.63 | GRK6 (1.00) | GRK6KDM4EALDH1A1SMN1; SMN2TDP1 | |
| Bromide SCHEMBL31741343 | 0.62 | GRK6 (0.96) | GRK6KDM4EALDH1A1HPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11423019 | 0.62 | GRK6 (0.96) | GRK6KDM4EALDH1A1SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210198671-A1 | PROTECTED ANTIBODY-DRUG AND APTAMER-DRUG CONJUGATES | KOSAK KENNETH MICHAEL (US) | 2021-07-01 | — | — | US | disclosed |
| US-20080051323-A1 | Chloroquine drug compositions and methods for their synthesis | KOSAK KENNETH M | 2008-02-28 | — | — | US | disclosed |
| WO-2007040469-A2 | CHLOROQUINE COUPLED COMPOSITIONS AND METHODS FOR THEIR SYNTHESIS | KOSAK KEN M (US) | 2007-04-12 | — | — | WO | disclosed |
| US-20060040879-A1 | Chloroquine coupled nucleic acids and methods for their synthesis | KOSAK KENNETH M | 2006-02-23 | — | — | US | disclosed |
| US-20050153913-A1 | Nucleic acid carrier compositions and methods for their synthesis | KOSAK KENNETH M (US) | 2005-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080051323-A1 | Chloroquine drug compositions and methods for their synthesis | CHMP4B, CTSA, CLTA | GRK6 1818/4885KDM4E 2091/4885ALDH1A1 4743/4885 |
| US-20210198671-A1 | PROTECTED ANTIBODY-DRUG AND APTAMER-DRUG CONJUGATES | ZFR, APP, RBM26 | GRK6 3699/4885KDM4E 4317/4885ALDH1A1 1853/4885 |
| US-20060040879-A1 | Chloroquine coupled nucleic acids and methods for their synthesis | TLR9, TLR3, EXOSC5 | GRK6 1387/4885KDM4E 3418/4885ALDH1A1 4696/4885 |
| US-20050153913-A1 | Nucleic acid carrier compositions and methods for their synthesis | DNA2, POLRMT, SLC29A2 | GRK6 2496/4885KDM4E 4804/4885ALDH1A1 2130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.