Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15155882 | 1.00 | ATM (0.55) | ATMTP53ALDH1A1MAPTMEN1 | |
| SCHEMBL12550512 | 0.88 | ALDH1A1 (0.54) | ATMTP53ALDH1A1MAPTMEN1 | |
| SCHEMBL2017690 | 0.87 | ALDH1A1 (0.56) | ATMTP53ALDH1A1MAPTMEN1 | |
| SCHEMBL13698360 | 0.84 | ATM (0.73) | ATMTP53ALDH1A1MAPTMEN1 | |
| Hydrochloric Acid SCHEMBL5827832 | 0.84 | ALDH1A1 (0.50) | ATMTP53ALDH1A1MAPTMEN1 | |
| SCHEMBL3219108 | 0.83 | MAPK1 (0.49) | ATMTP53ALDH1A1MAPTMEN1 | |
| SCHEMBL3219663 | 0.83 | SIGMAR1 (0.49) | ATMTP53ALDH1A1MAPTMEN1 | |
| SCHEMBL8877711 | 0.81 | ALDH1A1 (0.55) | ATMTP53ALDH1A1MAPTMEN1 | |
| SCHEMBL14267707 | 0.81 | SIGMAR1 (0.48) | ATMTP53ALDH1A1MAPTMEN1 | |
| SCHEMBL13698363 | 0.81 | ATM (0.54) | ATMTP53ALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879858-A2 | PROCESSES FOR PREPARING BIARYL UREAS AND ANALOGS THEREOF | Vertex Pharmaceuticals, Inc. (US) | 2008-01-23 | — | — | EP | claimed |
| WO-2006122072-A2 | PROCESSES FOR PREPARING BIARYL UREAS AND ANALOGS THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-11-16 | — | — | WO | claimed |
| US-20230055040-A1 | Synthesis Of Benzodiazepine Derivatives | TRIO MEDICINES LIMITED (GB) | 2023-02-23 | — | — | US | disclosed |
| EP-3331865-B1 | SYNTHESIS OF BENZODIAZEPINE DERIVATIVES | TRIO MEDICINES LTD (GB) | 2021-05-12 | — | — | EP | disclosed |
| US-10906884-B2 | Benzodiazepine derivatives as CCK2/gastrin receptor antagonists | TRIO MEDICINES LTD (GB) | 2021-02-02 | — | — | US | disclosed |
| US-20200223807-A1 | Synthesis Of Benzodiazepine Derivatives | TRIO MEDICINES LIMITED (GB) | 2020-07-16 | — | — | US | disclosed |
| US-10570102-B2 | Synthesis of benzodiazepine derivatives | TRIO MEDICINES LIMITED (GB) | 2020-02-25 | — | — | US | disclosed |
| EP-3180326-B1 | BENZODIAZEPINE DERIVATIVES AS CCK2/GASTRIN RECEPTOR ANTAGONISTS | TRIO MEDICINES LTD (GB) | 2019-10-23 | — | — | EP | disclosed |
| US-20190233391-A1 | Benzodiazepine Derivatives As CCK2/Gastrin Receptor Antagonists | TRIO MEDICINES LTD (GB) | 2019-08-01 | — | — | US | disclosed |
| US-10308627-B2 | Benzodiazepine derivatives as CCK2/gastrin receptor antagonists | TRIO MEDICINES LTD (GB) | 2019-06-04 | — | — | US | disclosed |
| US-20180237400-A1 | Synthesis Of Benzodiazepine Derivatives | TRIO MEDICINES LIMITED (GB) | 2018-08-23 | — | — | US | disclosed |
| US-20150174128-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE AVILOMICS RESEARCH, INC. (US) | 2015-06-25 | — | — | US | disclosed |
| EP-2809672-A1 | PURINONE COMPOUNDS AS KINASE INHIBITORS | Pharmacyclics, Inc. (US) | 2014-12-10 | — | — | EP | disclosed |
| WO-2014100748-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE AVILOMICS RESEARCH, INC. (US) | 2014-06-26 | — | — | WO | disclosed |
| US-20140179720-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | CELGENE AVILOMICS RESEARCH, INC. (US) | 2014-06-26 | — | — | US | disclosed |
| US-8697874-B2 | Heterocyclic compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-04-15 | — | — | US | disclosed |
| WO-2013116382-A1 | PURINONE COMPOUNDS AS KINASE INHIBITORS | PHARMACYCLICS, INC. (US) | 2013-08-08 | — | — | WO | disclosed |
| EP-2399921-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2011-12-28 | — | — | EP | disclosed |
| EP-1879858-A2 | PROCESSES FOR PREPARING BIARYL UREAS AND ANALOGS THEREOF | Vertex Pharmaceuticals, Inc. (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006122072-A2 | PROCESSES FOR PREPARING BIARYL UREAS AND ANALOGS THEREOF | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190233391-A1 | Benzodiazepine Derivatives As CCK2/Gastrin Receptor Antagonists | CCKBR, CCKAR, GRPR | ATM 3155/4885TP53 4475/4885ALDH1A1 2614/4885 |
| US-20200223807-A1 | Synthesis Of Benzodiazepine Derivatives | GABRA1, GABRA5, GABRE | ATM 3852/4885TP53 4883/4885ALDH1A1 590/4885 |
| US-10906884-B2 | Benzodiazepine derivatives as CCK2/gastrin receptor antagonists | CCKBR, CCKAR, GRPR | ATM 3155/4885TP53 4475/4885ALDH1A1 2614/4885 |
| US-20150174128-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | ABCG2, CYP3A43, CYP3A5 | ATM 4494/4885TP53 1214/4885ALDH1A1 684/4885 |
| US-10308627-B2 | Benzodiazepine derivatives as CCK2/gastrin receptor antagonists | CCKBR, CCKAR, GRPR | ATM 3155/4885TP53 4475/4885ALDH1A1 2614/4885 |
| US-20180237400-A1 | Synthesis Of Benzodiazepine Derivatives | GABRE, GABRA1, GABRA5 | ATM 3802/4885TP53 4881/4885ALDH1A1 644/4885 |
| US-10570102-B2 | Synthesis of benzodiazepine derivatives | GABRE, GABRA1, GABRA5 | ATM 3802/4885TP53 4881/4885ALDH1A1 644/4885 |
| US-20230055040-A1 | Synthesis Of Benzodiazepine Derivatives | GABRE, GABRA1, GABRA5 | ATM 3802/4885TP53 4881/4885ALDH1A1 644/4885 |
| US-20140179720-A1 | HETEROARYL COMPOUNDS AND USES THEREOF | ABCG2, CYP3A43, CYP3A5 | ATM 4494/4885TP53 1214/4885ALDH1A1 684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.