Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.40 |
| ▸ | SRPK1 | Q96SB4 | 3/20 | 0.40 |
| ▸ | FER | P16591 | 5/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.36 |
| ▸ | RET | P07949 | 2/20 | 0.36 |
| ▸ | FLT4 | P35916 | 2/20 | 0.36 |
| ▸ | CLK2 | P49760 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.36 |
| ▸ | BRSK1 | Q8TDC3 | 2/20 | 0.36 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4368419 | 0.91 | FER (0.36) | CHEK1RPS6KA3SRPK1FERACP1 | |
| SCHEMBL496442 | 0.89 | FER (0.34) | CHEK1RPS6KA3SRPK1FERACP1 | |
| SCHEMBL496253 | 0.81 | ALDH1A1 (0.42) | FERHTTRAB9AALDH1A1L3MBTL1 | |
| SCHEMBL4367918 | 0.81 | ALDH1A1 (0.42) | FERHTTRAB9AALDH1A1L3MBTL1 | |
| SCHEMBL496358 | 0.81 | CHEK1 (0.36) | CHEK1RPS6KA3SRPK1MAP4K4RET | |
| SCHEMBL496119 | 0.81 | FER (0.39) | CHEK1RPS6KA3SRPK1FERAR | |
| SCHEMBL16147403 | 0.76 | FGFR4 (0.39) | CHEK1RPS6KA3SRPK1FERAR | |
| SCHEMBL2712647 | 0.76 | FER (0.35) | FERACP1PTPN7PTPN12PTPN22 | |
| SCHEMBL9106184 | 0.76 | FER (0.35) | FERACP1PTPN7PTPN12PTPN22 | |
| SCHEMBL495955 | 0.74 | MEN1 (0.33) | CHEK1RPS6KA3SRPK1ALDH1A1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1955697-B1 | 2-AMINOBENZAMIDE DERIVATIVES AS VANILLOID RECEPTOR 1 (VR1) INHIBITORS USEFUL FOR THE TREATMENT OF PAIN OR BLADDER FUNCTION DISORDER | ASTELLAS PHARMA INC (JP) | 2012-05-02 | — | — | EP | disclosed |
| US-8106190-B2 | 2-aminobenzamide derivatives | ASTELLAS PHARMA INC. (JP) | 2012-01-31 | — | — | US | disclosed |
| US-20090233900-A1 | 2-AMINOBENZAMIDE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2009-09-17 | — | — | US | disclosed |
| EP-1955697-A1 | 2-AMINOBENZAMIDE DERIVATIVE | Astellas Pharma Inc. (JP) | 2008-08-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233900-A1 | 2-AMINOBENZAMIDE DERIVATIVE | TRPV1, TRPV2, TRPV5 | CHEK1 3364/4885RPS6KA3 4432/4885SRPK1 4220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.