Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 3/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4585907 | 0.81 | MAPT (0.37) | PTGS2MAPTKDM4ETHRBALOX15 | |
| SCHEMBL6631370 | 0.80 | PTGS2 (0.44) | PTGS2MAPTKDM4ETHRBALOX15 | |
| SCHEMBL4957168 | 0.80 | PTGS2 (0.44) | PTGS2MAPTKDM4ETHRBALOX15 | |
| SCHEMBL5133823 | 0.80 | MAPT (0.37) | PTGS2MAPTKDM4ETHRBALOX15 | |
| SCHEMBL5133824 | 0.80 | MAPT (0.37) | PTGS2MAPTKDM4ETHRBALOX15 | |
| SCHEMBL13105633 | 0.76 | NOD1 (0.35) | PTGS2SMN1; SMN2ALDH1A1NOD1CA12 | |
| SCHEMBL21939897 | 0.76 | PTGS2 (0.32) | PTGS2PTGS1 | |
| SCHEMBL12443668 | 0.76 | MAPT (0.34) | ITGB1ITGA4PTGS2MAPTKDM4E | |
| SCHEMBL4587971 | 0.76 | ALDH1A1 (0.36) | PTGS2MAPTKDM4ETHRBALOX15 | |
| SCHEMBL11773441 | 0.75 | SMN1; SMN2 (0.46) | ITGB1ITGA4PTGS2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378387-B2 | Method of suppressing immune response by reducing intracellular content of glutathione in macrophages and monocytes | AJINOMOTO CO., INC. (JP) | 2008-05-27 | — | — | US | disclosed |
| US-20050239886-A1 | Method of suppressing immune response by reducing intracellular content of glutathione in macrophages and monocytes | AJINOMOTO CO., INC. (JP) | 2005-10-27 | — | — | US | disclosed |
| US-20010000784-A1 | METHOD OF SUPRESSING IMMUNE RESPONSES BY REDUCING INTRACELLULAR CONTENT OF GLUTATHIONE IN MACROPHAGES AND MONOCYTES | AJINOMOTO CO. INC. (JP) | 2001-05-03 | — | — | US | disclosed |
| US-6197749-B1 | THERAPY FOR CANCER, DIABETES, GASTROINTESTINAL DISEASES, INFLAMMATION, ARTHRITIS | AJINOMOTO CO., INC. (JP) | 2001-03-06 | — | — | US | disclosed |
| EP-1004302-A2 | Immunomodulator | Ajinomoto Co., Ltd. (JP) | 2000-05-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010000784-A1 | METHOD OF SUPRESSING IMMUNE RESPONSES BY REDUCING INTRACELLULAR CONTENT OF GLUTATHIONE IN MACROPHAGES AND MONOCYTES | GSR, GPX1, CD14 | ITGB1 4152/4885ITGA4 4465/4885PTGS2 55/4885 |
| US-20050239886-A1 | Method of suppressing immune response by reducing intracellular content of glutathione in macrophages and monocytes | GSR, CD14, GPX1 | ITGB1 4101/4885ITGA4 4202/4885PTGS2 66/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.