Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4962109 | 0.90 | CYP1A2 (0.58) | CYP2C19CYP1A2CYP2D6NPC1CASP3 | |
| SCHEMBL4963360 | 0.85 | MAPT (0.53) | CYP2C19CYP1A2CYP2D6NPC1CASP3 | |
| SCHEMBL4960929 | 0.85 | MAPT (0.53) | CYP2C19CYP1A2CYP2D6NPC1CASP3 | |
| SCHEMBL4960921 | 0.81 | ALDH1A1 (0.50) | CYP2C19CYP1A2CYP2D6NPC1CASP3 | |
| SCHEMBL17266522 | 0.80 | CYP1A2 (0.90) | CYP2C19CYP1A2CYP2D6NPC1CASP3 | |
| SCHEMBL5151263 | 0.79 | RAB9A (0.58) | CYP2C19RAB9ASMN1; SMN2ALDH1A1NPSR1 | |
| SCHEMBL9084215 | 0.79 | CYP1A2 (0.88) | CYP2C19CYP1A2CYP2D6NPC1CASP3 | |
| SCHEMBL8914866 | 0.79 | CYP1A2 (0.88) | CYP2C19CYP1A2CYP2D6NPC1CASP3 | |
| SCHEMBL7276534 | 0.78 | HTR1A (0.47) | CYP2C19CYP1A2CYP2D6ALDH1A1NPSR1 | |
| SCHEMBL10959445 | 0.78 | RAB9A (0.63) | CYP2C19RAB9ASMN1; SMN2ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879900-A2 | SULFOXIMINE-PYRIMIDINE MACROCYCLES AND THE SALTS THEREOF, A PROCESS FOR MAKING THEM, AND THEIR PHARMACEUTICAL USE AGAINST CANCER | Bayer Schering Pharma Aktiengesellschaft (DE) | 2008-01-23 | — | — | EP | disclosed |
| US-20060252782-A1 | Sulfoximine-macrocycle compounds and salts thereof, pharmaceutical compositions comprising said compounds, methods of preparing same and uses of same | SCHERING AKTIENGESELLSCHAFT (DE) | 2006-11-09 | — | — | US | disclosed |
| WO-2006108695-A2 | SULFOXIMINE-PYRIMIDINE MACROCYCLES AND THE SALTS THEREOF , A PROCESS FOR MAKING THEM, AND THEIR PHARMACEUTICAL USE AGAINST CANCER | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2006-10-19 | — | — | WO | disclosed |
| EP-1710246-A1 | Sulfoximine-pyrimidine Macrocycles and the salts thereof, a process for making them, and their pharmaceutical use against cancer | Schering Aktiengesellschaft (DE) | 2006-10-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252782-A1 | Sulfoximine-macrocycle compounds and salts thereof, pharmaceutical compositions comprising said compounds, methods of preparing same and uses of same | TEK, FLT1, TIE1 | CYP2C19 1681/4885CYP1A2 1152/4885CYP2D6 2993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.