Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | PGR | P06401 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ACLY | P53396 | 2/20 | 0.40 |
| ▸ | IDH1 | O75874 | 3/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
| ▸ | ITGA1 | P56199 | 1/20 | 0.38 |
| ▸ | PKLR | P30613 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4524853 | 0.77 | PGR (0.39) | PKMPGRMAPTACLYIDH1 | |
| SCHEMBL4510370 | 0.75 | ALPL (0.38) | PKMPGRMAPTACLY | |
| SCHEMBL27940616 | 0.72 | PKLR (0.46) | PKMMAPTACLYPKLR | |
| SCHEMBL23415915 | 0.71 | PKM (0.48) | PKMMAPTACLY | |
| SCHEMBL4514681 | 0.70 | CNR2 (0.37) | MAPTACLYIDH1HSP90AA1HSP90AB1 | |
| SCHEMBL31696798 | 0.68 | MAPK1 (0.70) | PGRMAPTHSP90AA1HSP90AB1ITGA1 | |
| SCHEMBL21046810 | 0.68 | HTR3A (0.37) | PKMMAPTIDH1 | |
| SCHEMBL29682808 | 0.68 | HTR3A (0.37) | PKMMAPTIDH1 | |
| SCHEMBL23505785 | 0.66 | NOTUM (0.49) | — | |
| SCHEMBL27561521 | 0.66 | ALPL (0.69) | PGRACLYIDH1HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888518-A1 | NOVEL 8-SULFONYL-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR | AstraZeneca AB (SE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006126938-A1 | NOVEL 8-SULFONYL-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR | ASTRAZENECA AB (SE) | 2006-11-30 | — | — | WO | disclosed |