Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.65 |
| ▸ | CES1 | P23141 | 3/20 | 0.65 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1705293 | 0.96 | CES2 (0.65) | CES2CES1CA1CA2L3MBTL1 | |
| SCHEMBL4961638 | 0.82 | CES2 (0.50) | CES2CES1L3MBTL1GAANPC1 | |
| SCHEMBL8679191 | 0.80 | CA1 (0.52) | CES2CES1CA1CA2TDP1 | |
| SCHEMBL13291390 | 0.79 | CES2 (0.74) | CES2CES1L3MBTL1SNCANPC1 | |
| SCHEMBL8070666 | 0.79 | CES2 (1.00) | CES2CES1L3MBTL1SNCANPC1 | |
| SCHEMBL28742315 | 0.78 | CES2 (0.65) | CES2CES1CA1CA2NPC1 | |
| SCHEMBL5605898 | 0.77 | CES2 (0.71) | CES2CES1L3MBTL1GAASNCA | |
| SCHEMBL366061 | 0.77 | CES2 (0.71) | CES2CES1CA1CA2L3MBTL1 | |
| SCHEMBL7612594 | 0.77 | CES2 (0.71) | CES2CES1L3MBTL1GAASNCA | |
| SCHEMBL31384789 | 0.77 | CA2 (0.54) | CES2CES1CA1CA2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1314725-B1 | SULFONIUM SALT COMPOUND | WAKO PURE CHEM IND LTD (JP) | 2008-03-19 | — | — | EP | disclosed |
| EP-1314725-A1 | SULFONIUM SALT COMPOUND | Wako Pure Chemical Industries, Ltd. (JP) | 2003-05-28 | — | — | EP | disclosed |