Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 3/20 | 0.65 |
| ▸ | CES1 | P23141 | 3/20 | 0.65 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Silver SCHEMBL4962242 | 0.96 | CES2 (0.65) | CES2CES1CA1CA2L3MBTL1 | |
| SCHEMBL4961638 | 0.82 | CES2 (0.50) | CES2CES1L3MBTL1GAANPC1 | |
| SCHEMBL8679191 | 0.80 | CA1 (0.52) | CES2CES1CA1CA2TDP1 | |
| SCHEMBL13291390 | 0.79 | CES2 (0.74) | CES2CES1L3MBTL1SNCANPC1 | |
| SCHEMBL8070666 | 0.79 | CES2 (1.00) | CES2CES1L3MBTL1SNCANPC1 | |
| SCHEMBL28742315 | 0.78 | CES2 (0.65) | CES2CES1CA1CA2NPC1 | |
| SCHEMBL5605898 | 0.77 | CES2 (0.71) | CES2CES1L3MBTL1GAASNCA | |
| SCHEMBL366061 | 0.77 | CES2 (0.71) | CES2CES1CA1CA2L3MBTL1 | |
| SCHEMBL7612594 | 0.77 | CES2 (0.71) | CES2CES1L3MBTL1GAASNCA | |
| SCHEMBL31384789 | 0.77 | CA2 (0.54) | CES2CES1CA1CA2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2746250-B1 | Precursors and process for the production of 18F-labelled amino acids | ABX ADVANCED BIOCHEMICAL COMPOUNDS GMBH (DE) | 2017-09-27 | — | — | EP | disclosed |
| WO-2014095739-A1 | PRECURSORS AND PROCESS FOR THE PRODUCTION OF 18F-LABELLED AMINO ACIDS | ABX ADVANCED BIOCHEMICAL COMPOUNDS (DE) | 2014-06-26 | — | — | WO | disclosed |
| EP-2746250-A1 | Precursors and process for the production of 18F-labelled amino acids | ABX Advanced Biochemical Compounds GmbH (DE) | 2014-06-25 | — | — | EP | disclosed |
| EP-2357178-B1 | Process for the production of L-2-[18F]fluor-phenylalanine and 6-[18F]fluor-L-meta-tyrosine and their alpha-alkylated derivatives from a precursor. | FORSCHUNGSZENTRUM JUELICH GMBH (DE) | 2014-05-07 | — | — | EP | disclosed |
| EP-2336114-B1 | PROCESS FOR THE SYNTHESIS OF L-3,4 DIHYDROXY-6-[18F]FLUORO-PHENYLALANINE AND 2-[18F]FLUOR-L-TYROSINE AND THEIR ALPHA-METHYLATED DERIVATIVES STARTING FROM A PRECURSOR | FORSCHUNGSZENTRUM JUELICH GMBH (DE) | 2013-04-17 | — | — | EP | disclosed |
| US-20130060063-A1 | METHOD FOR PRODUCING PRECURSORS FOR L-3,4-DIHYDROXY-6-[18F]FLUOROPHENYLALANINE AND 2-[18F]FLUORO-L-TYROSINE AND THE A-METHYLATED DERIVATIVES THEREOF, PRECURSOR, AND METHOD FOR PRODUCING L-3,4DIHYDROXY-6-[18F]FLUOROPHENYLALANINE AND 2-[18F]FLUORO-L-TYROSINE AND THE A-METHYLATED DERIVATIVES FROM THE PRECURSOR | WAGNER FRANZISKA (DE) | 2013-03-07 | — | — | US | disclosed |
| US-8273793-B2 | Method for producing precursors for L-2- [18F] fluorophenylalanine and 6- [18F] fluoro-L—meta-tyrosine and the α-methylated derivatives thereof, precursor, and method for producing L-2- [18F] fluorophenylalanine and 6- [18F] fluoro-L-meta-tyrosine and the α-methylated derivatives from the precursor | FORSCHUNGSZENTRUM JUELICH GMBH (DE) | 2012-09-25 | — | — | US | disclosed |
| EP-2222644-B9 | METHOD FOR PRODUCING PRECURSORS FOR L-2-[18F]FLUOROPHENYLALANINE AND 6-[18F]FLUORO-L--META-TYROSINE AND THE ALPHA -METHYLATED DERIVATIVES THEREOF AND THE PRECURSORS | FORSCHUNGSZENTRUM JUELICH GMBH (DE) | 2012-04-18 | — | — | EP | disclosed |
| EP-2357178-A1 | Process for the production of L-2-[18F]fluor-phenylalanine and 6-[18F]fluor-L-meta-tyrosine and their alpha-alkylated derivatives from a precursor | Forschungszentrum Jülich GmbH (DE) | 2011-08-17 | — | — | EP | disclosed |
| EP-2220049-B1 | METHOD FOR PRODUCING PRECURSORS FOR L-3,4-DIHYDROXY-6-[18F]FLUOROPHENYLALANINE AND 2-[18F]FLUORO-L-TYROSINE AND THE ALPHA -METHYLATED DERIVATIVES THEREOF, AND THE PRECURSORS | FORSCHUNGSZENTRUM JUELICH GMBH (DE) | 2011-08-10 | — | — | EP | disclosed |
| EP-2222644-B1 | METHOD FOR PRODUCING PRECURSORS FOR L-2-[18F]FLUOROPHENYLALANINE AND 6-[18F]FLUORO-L--META-TYROSINE AND THE ALPHA -METHYLATED DERIVATIVES THEREOF AND THE PRECURSORS | FORSCHUNGSZENTRUM JUELICH GMBH (DE) | 2011-08-03 | — | — | EP | disclosed |
| EP-2336114-A1 | Process for the synthesis of L-3,4 dihydroxy-6-[18F]fluoro-phenylalanine and 2-[18F]Fluor-L-tyrosine and their alpha-methylated derivatives starting from a precursor | Forschungszentrum Jülich GmbH (DE) | 2011-06-22 | — | — | EP | disclosed |
| US-20100261913-A1 | METHOD FOR PRODUCING PRECURSORS FOR L-3,4-DIHYDROXY-6- [18F] FLUOROPHENYL ALAINE AND 2- [18F] FLUORO-L-TYROSINE AND THE ALPHA-METHYLATED DERIVATIVES THEREOF, PRECURSOR, AND METHOD FOR PRODUCING L-3, 4DIHYDROXY-6- [18F] FLUOROPHENYLALANINE AND 2- [18F] FLUORO-L-TYROSINE AND THE ALPHA-METHYLATED DERIVATIVES FROM THE PRECURSOR | FORSCHUNGSZENTRUM JUELICH GMBH (DE) | 2010-10-14 | — | — | US | disclosed |
| US-20100256389-A1 | METHOD FOR PRODUCING PRECURSORS FOR L-2- [18F] FLUOROPHENYLALANINE AND 6- [18F] FLUORO-L--META-TYROSINE AND THE ALPHA-METHYLATED DERIVATIVES THEREOF, PRECURSOR, AND METHOD FOR PRODUCING L-2- [18F] FLUOROPHENYLALANINE AND 6- [18F] FLUORO-L-META-TYROSINE AND THE ALPHA-METHYLATED DERIVATIVES FROM THE PRECURSOR | FORSCHUNGSZENTRUM JUELICH GMBH (DE) | 2010-10-07 | — | — | US | disclosed |
| EP-2222644-A2 | METHOD FOR PRODUCING PRECURSORS FOR L-2-[18F]FLUOROPHENYLALANINE AND 6-[18F]FLUORO-L--META-TYROSINE AND THE ALPHA -METHYLATED DERIVATIVES THEREOF, PRECURSOR, AND METHOD FOR PRODUCING L-2-[18F]FLUOROPHENYLALANINE AND 6-[18F]FLUORO-L-META-TYROSINE AND THE ALPHA-METHYLATED DERIVATIVES FROM THE PRECURSOR | Forschungszentrum Jülich GmbH (DE) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009071050-A2 | METHOD FOR PRODUCING PRECURSORS FOR L-2-[18F]FLUOROPHENYLALANINE AND 6-[18F]FLUORO-L--META-TYROSINE AND THE α-METHYLATED DERIVATIVES THEREOF, PRECURSOR, AND METHOD FOR PRODUCING L-2-[18F]FLUOROPHENYLALANINE AND 6-[18F]FLUORO-L-META-TYROSINE AND THE α-METHYLATED DERIVATIVES FROM THE PRECURSOR | Forschungszentrum Jülich GmbH (DE) | 2009-06-11 | — | — | WO | disclosed |
| EP-0497796-B1 | METHOD OF PREPARATION OF FLUOROBENZENES | HOECHST AG (DE) | 1994-06-22 | — | — | EP | disclosed |
| EP-0497796-A1 | METHOD OF PREPARATION OF FLUOROBENZENES. | HOECHST AG (DE) | 1992-08-12 | — | — | EP | disclosed |
| WO-1991006518-A1 | METHOD OF PREPARATION OF FLUOROBENZENES | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-05-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261913-A1 | METHOD FOR PRODUCING PRECURSORS FOR L-3,4-DIHYDROXY-6- [18F] FLUOROPHENYL ALAINE AND 2- [18F] FLUORO-L-TYROSINE AND THE ALPHA-METHYLATED DERIVATIVES THEREOF, PRECURSOR, AND METHOD FOR PRODUCING L-3, 4DIHYDROXY-6- [18F] FLUOROPHENYLALANINE AND 2- [18F] FLUORO-L-TYROSINE AND THE ALPHA-METHYLATED DERIVATIVES FROM THE PRECURSOR | TH, DAO, FTO | CES2 2406/4885CES1 3150/4885CA1 4475/4885 |
| US-20100256389-A1 | METHOD FOR PRODUCING PRECURSORS FOR L-2- [18F] FLUOROPHENYLALANINE AND 6- [18F] FLUORO-L--META-TYROSINE AND THE ALPHA-METHYLATED DERIVATIVES THEREOF, PRECURSOR, AND METHOD FOR PRODUCING L-2- [18F] FLUOROPHENYLALANINE AND 6- [18F] FLUORO-L-META-TYROSINE AND THE ALPHA-METHYLATED DERIVATIVES FROM THE PRECURSOR | TH, TYR, COMT | CES2 1544/4885CES1 3331/4885CA1 4677/4885 |
| US-20130060063-A1 | METHOD FOR PRODUCING PRECURSORS FOR L-3,4-DIHYDROXY-6-[18F]FLUOROPHENYLALANINE AND 2-[18F]FLUORO-L-TYROSINE AND THE A-METHYLATED DERIVATIVES THEREOF, PRECURSOR, AND METHOD FOR PRODUCING L-3,4DIHYDROXY-6-[18F]FLUOROPHENYLALANINE AND 2-[18F]FLUORO-L-TYROSINE AND THE A-METHYLATED DERIVATIVES FROM THE PRECURSOR | TH, FTO, PAH | CES2 2416/4885CES1 3292/4885CA1 4651/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.