Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10072942 | 1.00 | TRPM8 (0.64) | TRPM8SMN1; SMN2TSHRALOX15P2RX4 | |
| SCHEMBL2628744 | 0.90 | TRPM8 (0.60) | TRPM8SMN1; SMN2TSHRALOX15P2RX4 | |
| SCHEMBL15533401 | 0.87 | TRPM8 (0.55) | TRPM8P2RX4EPHX1 | |
| SCHEMBL2628781 | 0.86 | TRPM8 (0.74) | TRPM8SMN1; SMN2TAS1R3TAS1R1 | |
| SCHEMBL4886225 | 0.85 | TRPM8 (0.60) | TRPM8SMN1; SMN2TSHRP2RX4TDP1 | |
| SCHEMBL2628773 | 0.84 | TRPM8 (0.58) | TRPM8P2RX4EPHX1 | |
| SCHEMBL2628761 | 0.84 | TRPM8 (0.58) | TRPM8P2RX4L3MBTL1EPHX1NPC1 | |
| SCHEMBL4812089 | 0.84 | P2RX4 (0.61) | TRPM8P2RX4EPHX1 | |
| SCHEMBL2628771 | 0.83 | TRPM8 (0.57) | TRPM8TSHRP2RX4TAS1R3TAS1R1 | |
| SCHEMBL4883688 | 0.82 | TRPM8 (0.56) | TRPM8TSHRP2RX4TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233046-B1 | USE OF A COMBINATION OF AN ASSOCIATIVE NONIONIC POLYETHER POLYURETHANE AND A CYCLOHEXANOL DERIVATIVE AS A SKIN REFRESHING AGENT | OREAL (FR) | 2020-07-29 | — | — | EP | disclosed |
| US-10548833-B2 | Use of a combination of an associative nonionic polyether polyurethane and a cyclohexanol derivative as a skin refreshing agent | L'OREAL (FR) | 2020-02-04 | — | — | US | disclosed |
| US-20170367965-A1 | USE OF A COMBINATION OF AN ASSOCIATIVE NONIONIC POLYETHER POLYURETHANE AND A CYCLOHEXANOL DERIVATIVE AS A SKIN REFRESHING AGENT | L'OREAL (FR) | 2017-12-28 | — | — | US | disclosed |
| EP-3233046-A1 | USE OF A COMBINATION OF AN ASSOCIATIVE NONIONIC POLYETHER POLYURETHANE AND A CYCLOHEXANOL DERIVATIVE AS A SKIN REFRESHING AGENT | L'Oréal (FR) | 2017-10-25 | — | — | EP | disclosed |
| WO-2016096928-A1 | USE OF A COMBINATION OF AN ASSOCIATIVE NONIONIC POLYETHER POLYURETHANE AND A CYCLOHEXANOL DERIVATIVE AS A SKIN REFRESHING AGENT | L'OREAL (FR) | 2016-06-23 | — | — | WO | disclosed |
| EP-1871738-A2 | N-ALKYLCARBONYL-AMINO ACID ESTER AND N-ALKYLCARBONYL-AMINO LACTONE COMPOUNDS AND THEIR USE | Wei, Edward T. (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006103401-A2 | N-ALKYLCARBONYL-AMINO ACID ESTER AND N-ALKYLCARBONYL-AMINO LACTONE COMPOUNDS AND THEIR USE | PAGET, HUGH, CHARLES, EDWARD (GB) | 2006-10-05 | — | — | WO | disclosed |
| US-20050187211-A1 | N-arylsalkyl-carboxamide compositions and methods | WEI EDWARD T (US) | 2005-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10548833-B2 | Use of a combination of an associative nonionic polyether polyurethane and a cyclohexanol derivative as a skin refreshing agent | CUTA, DEGS1, OR51E2 | TRPM8 16/4885SMN1; SMN2 4493/4885TSHR 3335/4885 |
| US-20050187211-A1 | N-arylsalkyl-carboxamide compositions and methods | OPRL1, TRPV1, TRPA1 | TRPM8 13/4885SMN1; SMN2 334/4885TSHR 3809/4885 |
| US-20170367965-A1 | USE OF A COMBINATION OF AN ASSOCIATIVE NONIONIC POLYETHER POLYURETHANE AND A CYCLOHEXANOL DERIVATIVE AS A SKIN REFRESHING AGENT | CUTA, DEGS1, OR51E2 | TRPM8 16/4885SMN1; SMN2 4493/4885TSHR 3335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.