Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 4/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.37 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CEL | P19835 | 1/20 | 0.35 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1160572 | 0.83 | NUDT1 (0.45) | NUDT1BACE1HSP90AA1FEN1HDAC4 | |
| SCHEMBL11319506 | 0.82 | NUDT1 (0.44) | NUDT1BACE1HSP90AA1FEN1HDAC4 | |
| SCHEMBL6361815 | 0.82 | FEN1 (0.37) | FEN1HDAC4HDAC2HDAC8ALOX5AP | |
| SCHEMBL10607806 | 0.81 | NUDT1 (0.46) | NUDT1BACE1HSP90AA1FEN1HDAC4 | |
| SCHEMBL12909319 | 0.80 | NUDT1 (0.39) | NUDT1BACE1HSP90AA1HDAC4HDAC2 | |
| SCHEMBL20676750 | 0.80 | FEN1 (0.39) | NUDT1BACE1HSP90AA1FEN1ALOX5AP | |
| SCHEMBL9340143 | 0.80 | ACMSD (0.46) | NUDT1BACE1HSP90AA1HDAC4HDAC2 | |
| SCHEMBL4962052 | 0.79 | CHRNB2 (0.55) | NUDT1BACE1HSP90AA1HDAC4HDAC2 | |
| SCHEMBL11764867 | 0.79 | NUDT1 (0.41) | NUDT1BACE1HSP90AA1FEN1HDAC4 | |
| SCHEMBL3169205 | 0.78 | HDAC4 (0.52) | HDAC4HDAC2HDAC8ACMSDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1628945-B1 | DEPIGMENTING AGENTS | WARNER LAMBERT CO (US) | 2008-08-20 | — | — | EP | disclosed |
| US-7390838-B2 | Depigmenting agents | PFIZER INC. (US) | 2008-06-24 | — | — | US | disclosed |
| US-7338979-B2 | Depigmentation agents | WARNER-LAMBERT COMPANY (US) | 2008-03-04 | — | — | US | disclosed |
| EP-1628945-A1 | DEPIGMENTING AGENTS | Warner-Lambert Company LLC (US) | 2006-03-01 | — | — | EP | disclosed |
| EP-1594830-A1 | DEPIGMENTATION AGENTS | Warner-Lambert Company LLC (US) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004103940-A1 | DEPIGMENTING AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2004-12-02 | — | — | WO | disclosed |
| US-20040235963-A1 | Depigmenting agents | GATTRELL WILLIAM THOMAS (GB) | 2004-11-25 | — | — | US | disclosed |
| US-20040186186-A1 | Depigmentation agents | PROCTER MARTIN JAMES (GB) | 2004-09-23 | — | — | US | disclosed |
| WO-2004072010-A1 | DEPIGMENTATION AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2004-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040186186-A1 | Depigmentation agents | NQO1, ADH4, ALDH1A2 | NUDT1 698/4885BACE1 3565/4885HSP90AA1 2066/4885 |
| US-20040235963-A1 | Depigmenting agents | NQO1, ADH4, ALDH1A2 | NUDT1 633/4885BACE1 2201/4885HSP90AA1 2321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.