Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 7/20 | 0.67 |
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3979943 | 0.83 | PRKCZ (0.61) | PRKCZMAPTALDH1A1MAPK1HPGD | |
| SCHEMBL3976440 | 0.81 | PRKCZ (0.59) | PRKCZMAPTALDH1A1MAPK1TSHR | |
| SCHEMBL4962826 | 0.81 | PRKCZ (0.61) | PRKCZMAPTALDH1A1MAPK1HPGD | |
| SCHEMBL11518208 | 0.80 | PRKCZ (1.00) | PRKCZMAPTALDH1A1MAPK1HPGD | |
| SCHEMBL4469939 | 0.73 | PRKCZ (0.50) | PRKCZMAPTALDH1A1HPGDHSD17B10 | |
| SCHEMBL4477288 | 0.73 | TSHR (0.47) | PRKCZMAPTALDH1A1MAPK1TSHR | |
| SCHEMBL15063946 | 0.73 | KDR (0.53) | PRKCZMAPTALDH1A1MAPK1TSHR | |
| SCHEMBL14825156 | 0.72 | EPHB4 (0.55) | PRKCZMAPTALDH1A1MAPK1HPGD | |
| Urea SCHEMBL28797638 | 0.71 | TSHR (0.65) | MAPTALDH1A1MAPK1TSHRGAA | |
| SCHEMBL4492436 | 0.70 | TSHR (0.44) | PRKCZMAPTALDH1A1MAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436279-B8 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-10-29 | — | — | EP | disclosed |
| EP-1436279-B1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-08-13 | — | — | EP | disclosed |
| US-7179836-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-20 | — | — | US | disclosed |
| EP-1436279-A4 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2005-10-26 | — | — | EP | disclosed |
| US-20040192941-A1 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2004-09-30 | — | — | US | disclosed |
| EP-1436279-A1 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003027093-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192941-A1 | Chemical compounds | TPMT, TST, CYP11B2 | PRKCZ 4039/4885MAPT 1014/4885ALDH1A1 165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.