Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | MC4R | P32245 | 2/20 | 0.48 |
| ▸ | MC3R | P41968 | 2/20 | 0.48 |
| ▸ | MC1R | Q01726 | 2/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
| ▸ | TACR3 | P29371 | 1/20 | 0.45 |
| ▸ | ABHD6 | Q9BV23 | 4/20 | 0.45 |
| ▸ | DAGLA | Q9Y4D2 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18862950 | 1.00 | HSD11B1 (0.48) | HSD11B1MC4RMC3RMC1RABCB1 | |
| SCHEMBL908981 | 0.90 | SCD5 (0.57) | HSD11B1MC4RMC3RMC1RSCD5 | |
| SCHEMBL23459127 | 0.90 | SCD5 (0.57) | HSD11B1MC4RMC3RMC1RSCD5 | |
| SCHEMBL4964339 | 0.88 | HSD11B1 (0.61) | HSD11B1SCD5GABRA1GABRG2GABRB3 | |
| SCHEMBL4629395 | 0.88 | HSD11B1 (0.61) | HSD11B1SCD5GABRA1GABRG2GABRB3 | |
| Hydrochloric Acid SCHEMBL29238125 | 0.87 | HSD11B1 (0.60) | HSD11B1SCD5GABRA1GABRG2GABRB3 | |
| SCHEMBL11760424 | 0.86 | HSD11B1 (0.46) | HSD11B1MC4RMC3RMC1RABCB1 | |
| SCHEMBL5800629 | 0.86 | TACR1 (0.46) | HSD11B1MC4RMC3RMC1RABCB1 | |
| SCHEMBL13722390 | 0.85 | TACR1 (0.46) | HSD11B1MC4RMC3RMC1RABCB1 | |
| SCHEMBL29187960 | 0.85 | TACR1 (0.52) | HSD11B1MC4RMC3RMC1RABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3186224-B1 | SUBSTITUTED AZETIDINE DERIVATIVES AS TAAR LIGANDS | HOFFMANN LA ROCHE (CH) | 2021-04-21 | — | — | EP | disclosed |
| US-10023559-B2 | Substituted azetidine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2018-07-17 | — | — | US | disclosed |
| US-20170144994-A1 | SUBSTITUTED AZETIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2017-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10023559-B2 | Substituted azetidine derivatives | HTR1B, MTNR1B, DRD2 | HSD11B1 766/4885MC4R 1088/4885MC3R 1501/4885 |
| US-20170144994-A1 | SUBSTITUTED AZETIDINE DERIVATIVES | HTR1B, MTNR1B, DRD2 | HSD11B1 766/4885MC4R 1088/4885MC3R 1501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.