Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4963200 | 0.96 | ALDH1A1 (0.55) | ALDH1A1PKMFFAR4KDM1AMAOA | |
| SCHEMBL4968653 | 0.92 | GLO1 (0.48) | ALDH1A1PKMKDM1AMAOASMN1; SMN2 | |
| SCHEMBL4963573 | 0.87 | KDM4E (0.51) | ALDH1A1PKMKDM1AMAOASMN1; SMN2 | |
| SCHEMBL4966458 | 0.84 | PKM (0.51) | ALDH1A1PKMKDM1AMAOAHTT | |
| SCHEMBL4968749 | 0.80 | SMN1; SMN2 (0.56) | ALDH1A1PKMSMN1; SMN2LMNAHTT | |
| SCHEMBL4965545 | 0.79 | KMT2A (0.46) | ALDH1A1PKMKDM1AMAOASMN1; SMN2 | |
| SCHEMBL4962685 | 0.78 | MEN1 (0.60) | ALDH1A1PKMKDM1AMAOASMN1; SMN2 | |
| SCHEMBL4965824 | 0.78 | KMT2A (0.51) | ALDH1A1PKMKDM1AMAOAMEN1 | |
| SCHEMBL4966790 | 0.77 | KDM1A (0.45) | ALDH1A1KDM1AMAOAMEN1KMT2A | |
| SCHEMBL4964738 | 0.77 | KMT2A (0.50) | ALDH1A1PKMKDM1ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888544-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-02-20 | — | — | EP | claimed |
| WO-2006066109-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | claimed |
| EP-1888544-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006066109-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | disclosed |