Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 3/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4967543 | 0.96 | KMT2A (0.42) | KMT2AMEN1ALDH1A1POLBPKM | |
| SCHEMBL4967467 | 0.83 | KMT2A (0.42) | KMT2AMEN1ALDH1A1POLBPKM | |
| SCHEMBL4962933 | 0.83 | KMO (0.43) | KMT2AALDH1A1PKMHSD11B1SCN8A | |
| SCHEMBL4962582 | 0.82 | HSD11B1 (0.41) | KMT2AALDH1A1PKMHSD11B1SCN8A | |
| SCHEMBL4962949 | 0.81 | KMT2A (0.40) | KMT2AMEN1ALDH1A1POLBPKM | |
| SCHEMBL4963972 | 0.81 | PKM (0.48) | KMT2AMEN1ALDH1A1POLBPKM | |
| SCHEMBL4962604 | 0.81 | KMT2A (0.49) | KMT2AMEN1ALDH1A1POLBPKM | |
| SCHEMBL4964911 | 0.80 | KMT2A (0.44) | KMT2AMEN1ALDH1A1POLBPKM | |
| SCHEMBL4964684 | 0.79 | KMT2A (0.41) | KMT2AMEN1ALDH1A1POLBPKM | |
| SCHEMBL4966262 | 0.78 | KMT2A (0.40) | KMT2AMEN1ALDH1A1POLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888544-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | Takeda San Diego, Inc. (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006066109-A2 | HYDROXYSTEROID DEHYDROGENASE INHIBITORS | TAKEDA SAN DIEGO, INC. (US) | 2006-06-22 | — | — | WO | disclosed |