Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8590584 | 0.76 | KDM4E (0.43) | GAASLC9A1L3MBTL1ALDH1A1HPGD | |
| SCHEMBL23959122 | 0.73 | OPRK1 (0.43) | GSK3BHTR2BTSHR | |
| SCHEMBL14939598 | 0.68 | RAB9A (0.63) | SLC6A3MAPTGAAL3MBTL1HTR2B | |
| SCHEMBL16634786 | 0.68 | MAPT (0.49) | SLC6A3MAPTGAAALDH1A1HPGD | |
| SCHEMBL6288724 | 0.67 | LMNA (0.39) | MAPTGAAGSK3BHTR2BALDH1A1 | |
| SCHEMBL29462691 | 0.66 | SLC6A3 (0.38) | SLC6A3FFAR1 | |
| SCHEMBL28737258 | 0.66 | SLC6A3 (0.38) | SLC6A3FFAR1 | |
| Hydrochloric Acid SCHEMBL9138618 | 0.66 | MGLL (0.46) | MAPTGAAL3MBTL1ALDH1A1HPGD | |
| SCHEMBL23959045 | 0.66 | RAB9A (0.46) | SLC6A3MAPTGAAGSK3BL3MBTL1 | |
| SCHEMBL27934086 | 0.65 | LMNA (0.47) | SLC6A3MAPTGAASLC9A1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896412-A2 | OXINDOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2008-03-12 | — | — | EP | disclosed |
| WO-2006136606-A2 | OXINDOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-12-28 | — | — | WO | disclosed |