Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.33 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.33 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4966117 | 0.91 | MAPK14 (0.36) | TRPM8MAPK14DRD3HDAC1CXCR3 | |
| SCHEMBL4965081 | 0.87 | OPRM1 (0.36) | MAPK14DRD3HDAC1HDAC6CXCR3 | |
| SCHEMBL4965899 | 0.83 | CXCR3 (0.33) | DRD3CXCR3 | |
| SCHEMBL4968447 | 0.79 | BCHE (0.35) | ACHECXCR3 | |
| SCHEMBL14369641 | 0.75 | OPRM1 (0.39) | TRPM8ACHEDRD3 | |
| SCHEMBL14178521 | 0.73 | TAS1R3 (0.39) | HDAC1HDAC6 | |
| SCHEMBL14398038 | 0.72 | CYP4F2 (0.32) | CXCR3 | |
| Trifluoroacetic Acid SCHEMBL4967345 | 0.72 | TRPM8 (0.37) | TRPM8 | |
| SCHEMBL14398822 | 0.69 | CXCR3 (0.32) | CXCR3 | |
| SCHEMBL14369648 | 0.66 | F2 (0.34) | TRPM8MAPK14CXCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730140-B1 | OPIOID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-06-25 | — | — | EP | claimed |