Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HTR2B | P41595 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4963859 | 0.81 | GABRA1 (0.44) | GABRA1GABRG2GABRB3HTR2CHTR1A | |
| SCHEMBL4966050 | 0.78 | GABRA1 (0.38) | GABRA1GABRG2GABRB3HTR1ASLC6A2 | |
| Hydrochloric Acid SCHEMBL4966442 | 0.78 | GABRA1 (0.38) | GABRA1GABRG2GABRB3HTR1ASLC6A2 | |
| SCHEMBL4964907 | 0.73 | PLAT (0.35) | — | |
| SCHEMBL4977286 | 0.72 | HTR6 (0.38) | HTR2CHTR2BHTR2AHTR1ASLC6A2 | |
| SCHEMBL4977909 | 0.71 | CXCR2 (0.34) | HTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4965972 | 0.65 | HTR6 (0.44) | HTR2CHTR2BHTR1ASLC6A2SLC6A4 | |
| SCHEMBL11498275 | 0.65 | SLC6A2 (0.50) | GABRA1GABRG2GABRB3HTR2CHTR2B | |
| SCHEMBL4964731 | 0.64 | KIT (0.42) | SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL11198045 | 0.64 | SLC6A2 (0.49) | GABRA1GABRG2GABRB3HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904483-A1 | BENZIMIDAZOLE DERIVATIVES AS 5-HT6,5-HT24 | F. Hoffmann-Roche AG (CH) | 2008-04-02 | — | — | EP | claimed |
| WO-2007006677-A1 | BENZIMIDAZOLE DERIVATIVES AS 5-HT6,5-HT24 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-18 | — | — | WO | claimed |