Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 3/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.32 |
| ▸ | HTR1A | P08908 | 3/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.32 |
| ▸ | MPO | P05164 | 1/20 | 0.31 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4977286 | 0.84 | HTR6 (0.38) | SLC6A2SLC6A4HTR1ASLC6A3MPO | |
| SCHEMBL4966050 | 0.82 | GABRA1 (0.38) | SLC6A2SLC6A4HTR1ASLC6A3 | |
| Hydrochloric Acid SCHEMBL4966442 | 0.81 | GABRA1 (0.38) | SLC6A2SLC6A4HTR1ASLC6A3 | |
| SCHEMBL4965972 | 0.78 | HTR6 (0.44) | SLC6A2SLC6A4HTR1ASLC6A3 | |
| SCHEMBL4965409 | 0.71 | GABRA1 (0.40) | SLC6A2SLC6A4HTR1ASLC6A3 | |
| SCHEMBL4967691 | 0.67 | HTR6 (0.39) | SLC6A2SLC6A4HTR1ASLC6A3 | |
| SCHEMBL1824314 | 0.66 | CHRNB2 (0.49) | SLC6A2SLC6A4HTR1ASLC6A3 | |
| SCHEMBL4964731 | 0.64 | KIT (0.42) | CHRM1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4303824 | 0.64 | TNKS (0.37) | — | |
| SCHEMBL3880927 | 0.63 | CHRM1 (0.38) | CHRM1SLC6A2SLC6A4HTR1ASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904483-A1 | BENZIMIDAZOLE DERIVATIVES AS 5-HT6,5-HT24 | F. Hoffmann-Roche AG (CH) | 2008-04-02 | — | — | EP | claimed |
| WO-2007006677-A1 | BENZIMIDAZOLE DERIVATIVES AS 5-HT6,5-HT24 | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-18 | — | — | WO | claimed |