Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.40 |
| ▸ | CHRNG | P07510 | 1/20 | 0.40 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27626880 | 0.95 | PTGDR2 (0.50) | PTGDR2CYP11B2NOS3NOS1NOS2 | |
| SCHEMBL10865411 | 0.80 | CYP11B2 (0.36) | PTGDR2CYP11B2DRD2DRD3KDM4E | |
| SCHEMBL29519663 | 0.79 | GABRG2 (0.43) | CYP11B2KDM4EHPGDNPSR1CHRNA1 | |
| SCHEMBL27450587 | 0.78 | CYP11B2 (0.35) | PTGDR2CYP11B2DRD2DRD3KDM4E | |
| SCHEMBL28442339 | 0.78 | CNR1 (0.39) | PTGDR2CYP11B2KDM4EMEN1ALDH1A1 | |
| SCHEMBL15767956 | 0.77 | GRIA1 (0.37) | PTGDR2CYP11B2DRD2DRD3KDM4E | |
| SCHEMBL16905238 | 0.76 | CHRNA1 (0.59) | PTGDR2CYP11B2NOS3NOS1NOS2 | |
| SCHEMBL27626879 | 0.76 | PTGS2 (0.56) | PTGDR2CYP11B2ALDH1A1CYP19A1CYP11B1 | |
| SCHEMBL10606461 | 0.76 | KDM1A (0.45) | PTGDR2CYP11B2DRD2DRD3TSHR | |
| SCHEMBL4983356 | 0.75 | CHRNB2 (0.40) | PTGDR2CYP11B2MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888523-A2 | CYCLOBUTYL AMINE DERIVATIVES | Abbott Laboratories (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006132914-A2 | CYCLOBUTYL AMINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2006-12-14 | — | — | WO | disclosed |