Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.57 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.53 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.50 |
| ▸ | HPGDS | O60760 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1935816 | 0.94 | HSD11B1 (0.61) | PDE4BHSD11B1USP30NAMPTP2RY14 | |
| SCHEMBL226854 | 0.92 | NAMPT (0.59) | PDE4BNAMPTP2RY14HPGDSKMT2A | |
| SCHEMBL15376005 | 0.89 | RORC (0.49) | PDE4BHSD11B1USP30NAMPTP2RY14 | |
| SCHEMBL9409412 | 0.88 | PDE4B (0.59) | PDE4BUSP30NAMPTHPGDSKMT2A | |
| SCHEMBL23951735 | 0.88 | TP53 (0.59) | PDE4BUSP30NAMPTHPGDSTP53 | |
| SCHEMBL697513 | 0.88 | TP53 (0.59) | PDE4BUSP30NAMPTHPGDSTP53 | |
| SCHEMBL1751432 | 0.88 | TP53 (0.59) | PDE4BUSP30NAMPTHPGDSTP53 | |
| SCHEMBL18937651 | 0.86 | PDE4B (0.60) | PDE4BNAMPTHPGDSTP53GPR119 | |
| SCHEMBL12321142 | 0.86 | PDE4B (0.60) | PDE4BNAMPTKMT2ATP53GPR119 | |
| SCHEMBL1827362 | 0.85 | PDE4B (0.58) | PDE4BNAMPTKMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170135994-A9 | NAMPT INHIBITORS | ABBVIE INC. (US) | 2017-05-18 | — | — | US | disclosed |
| US-20160184281-A1 | NAMPT INHIBITORS | ABBVIE INC. (US) | 2016-06-30 | — | — | US | disclosed |
| US-20160184282-A1 | NAMPT INHIBITORS | ABBVIE INC. (US) | 2016-06-30 | — | — | US | disclosed |
| US-9193723-B2 | NAMPT inhibitors | ABBVIE INC. (US) | 2015-11-24 | — | — | US | disclosed |
| US-9187472-B2 | NAMPT inhibitors | ABBVIE INC. (US) | 2015-11-17 | — | — | US | disclosed |
| EP-2847192-A1 | NAMPT INHIBITORS | AbbVie Inc. (US) | 2015-03-18 | — | — | EP | disclosed |
| CN-104428301-A | NAMPT inhibitors | ABBVIE INC | 2015-03-18 | — | — | CN | disclosed |
| US-20140296235-A1 | 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS | ABBVIE INC. | 2014-10-02 | — | — | US | disclosed |
| US-8697736-B2 | 1H-benzimidazole-4-carboxamides substituted with phenyl at the 2-position are potent PARP inhibitors | ABBVIE INC. (US) | 2014-04-15 | — | — | US | disclosed |
| US-20130303508-A1 | NAMPT INHIBITORS | ABBVIE INC. (US) | 2013-11-14 | — | — | US | disclosed |
| WO-2007041357-A1 | 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS | ABBOTT LABORATORIES (US) | 2007-04-12 | — | — | WO | disclosed |
| EP-1031563-B1 | SULFONYL DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2005-12-28 | — | — | EP | disclosed |
| EP-1577302-A1 | NOVEL ETHYLENEDIAMINE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2005-09-21 | — | — | EP | disclosed |
| US-6747023-B1 | INHIBITORS FOR ACTIVATED COAGULATION FACTOR X, COAGULATION SUPPRESSORS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2004-06-08 | — | — | US | disclosed |
| US-20040082611-A1 | Anticoagulants; brain disorders; respiratory system disorders; side effect reduction | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2004-04-29 | — | — | US | disclosed |
| US-20030232808-A1 | Sulfonyl derivatives | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-12-18 | — | — | US | disclosed |
| US-6525042-B1 | Inhibits an activated coagulation factor FXa; anticoagulant, antithrombotic | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-02-25 | — | — | US | disclosed |
| EP-1104754-A1 | NOVEL SULFONYL DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2001-06-06 | — | — | EP | disclosed |
| EP-1031563-A1 | SULFONYL DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2000-08-30 | — | — | EP | disclosed |
| EP-0604800-A1 | 4- 4- 4-(carboxyalkyl)-phenyl amino carbonyl -phenyl -piperedines as aggregation inhibitors | Dr. Karl Thomae GmbH (DE) | 1994-07-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082611-A1 | Anticoagulants; brain disorders; respiratory system disorders; side effect reduction | F2, CYC1, SULT2A1 | PDE4B 4700/4885HSD11B1 2102/4885USP30 3755/4885 |
| US-20130303508-A1 | NAMPT INHIBITORS | NAMPT, NNMT, NAPRT | PDE4B 770/4885HSD11B1 2533/4885USP30 4391/4885 |
| US-20160184282-A1 | NAMPT INHIBITORS | NAMPT, NNMT, NAPRT | PDE4B 770/4885HSD11B1 2533/4885USP30 4391/4885 |
| US-20140296235-A1 | 1H-BENZIMIDAZOLE-4-CARBOXAMIDES SUBSTITUTED WITH PHENYL AT THE 2-POSITION ARE POTENT PARP INHIBITORS | PARP1, PARP2, PARP4 | PDE4B 1613/4885HSD11B1 2566/4885USP30 2894/4885 |
| US-20160184281-A1 | NAMPT INHIBITORS | NAMPT, NNMT, NAPRT | PDE4B 770/4885HSD11B1 2533/4885USP30 4391/4885 |
| US-20030232808-A1 | Sulfonyl derivatives | SULT1E1, SULT2A1, SULT1A1 | PDE4B 4532/4885HSD11B1 1592/4885USP30 3419/4885 |
| US-20170135994-A9 | NAMPT INHIBITORS | NAMPT, NNMT, NAPRT | PDE4B 770/4885HSD11B1 2533/4885USP30 4391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.