Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.45 |
| ▸ | BCHE | P06276 | 3/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4965638 | 0.86 | OPRM1 (0.41) | OPRM1OPRD1OPRK1S1PR1S1PR3 | |
| SCHEMBL4963457 | 0.85 | SLC2A1 (0.42) | OPRM1OPRD1OPRK1S1PR1S1PR3 | |
| SCHEMBL4965138 | 0.85 | MCHR1 (0.43) | NPC1POLBRAB9AMEN1KMT2A | |
| SCHEMBL4968096 | 0.85 | OPRM1 (0.49) | OPRM1OPRD1OPRK1BCHENPC1 | |
| SCHEMBL4966629 | 0.84 | SLC2A1 (0.37) | OPRM1OPRD1OPRK1S1PR1S1PR3 | |
| SCHEMBL4967478 | 0.83 | KDM4E (0.49) | NPC1POLBRAB9AMEN1KMT2A | |
| SCHEMBL4967496 | 0.82 | OPRM1 (0.46) | OPRM1OPRD1OPRK1NPC1POLB | |
| SCHEMBL4965646 | 0.82 | OPRM1 (0.41) | OPRM1OPRD1OPRK1NPC1POLB | |
| SCHEMBL4965252 | 0.82 | OPRM1 (0.41) | OPRM1OPRD1OPRK1NPC1POLB | |
| SCHEMBL4966564 | 0.81 | MEN1 (0.44) | BCHEPOLBMEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730140-B1 | OPIOID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-06-25 | — | — | EP | claimed |