Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4965138 | 0.90 | MCHR1 (0.43) | KDM4EKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL4965638 | 0.89 | OPRM1 (0.41) | SMN1; SMN2LMNASLC2A1 | |
| SCHEMBL4963457 | 0.88 | SLC2A1 (0.42) | LMNASLC2A1 | |
| SCHEMBL4966870 | 0.86 | KDM4E (0.46) | KDM4EKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL4966629 | 0.85 | SLC2A1 (0.37) | KDM4EKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL4965633 | 0.83 | OPRM1 (0.45) | KMT2AMEN1HTTRAB9ANPC1 | |
| SCHEMBL4966256 | 0.83 | AURKA (0.35) | KDM4EKMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL4965646 | 0.83 | OPRM1 (0.41) | KMT2AALDH1A1MEN1SMN1; SMN2LMNA | |
| SCHEMBL4965252 | 0.83 | OPRM1 (0.41) | KDM4EKMT2AMEN1RAB9ASLC2A1 | |
| Hydrochloric Acid SCHEMBL4965277 | 0.82 | OPRM1 (0.41) | KMT2AALDH1A1MEN1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730140-B1 | OPIOID RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-06-25 | — | — | EP | claimed |