Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 10/20 | 0.52 |
| ▸ | CCR5 | P51681 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4969428 | 0.91 | SIGMAR1 (0.50) | CCR3CCR5SIGMAR1HTR1ACYP2C9 | |
| SCHEMBL4968189 | 0.87 | CCR3 (0.51) | CCR3SIGMAR1HTR1ACYP2C9CYP2C19 | |
| SCHEMBL4967412 | 0.81 | CCR3 (0.55) | CCR3SIGMAR1MEN1KMT2A | |
| SCHEMBL4968976 | 0.78 | CCR3 (0.57) | CCR3CCR5MEN1KMT2AKDM4E | |
| SCHEMBL4969395 | 0.76 | LIPG (0.57) | CCR3CCR5SIGMAR1HTR2A | |
| SCHEMBL4969159 | 0.75 | HRH1 (0.57) | CCR3 | |
| SCHEMBL4968718 | 0.75 | HRH1 (0.62) | CCR3 | |
| SCHEMBL4968548 | 0.72 | HRH1 (0.58) | CCR3 | |
| SCHEMBL4965105 | 0.72 | CCR3 (0.49) | CCR3CCR5HTR2A | |
| SCHEMBL4155971 | 0.71 | CCR3 (0.57) | CCR3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1625114-B1 | Piperidine derivatives for the the treatment of chemokine or H1 mediated diseases | ASTRAZENECA AB (SE) | 2008-08-27 | — | — | EP | disclosed |