Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | BCHE | P06276 | 2/20 | 0.57 |
| ▸ | ACHE | P22303 | 2/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.56 |
| ▸ | THRA | P10827 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.54 |
| ▸ | LSS | P48449 | 1/20 | 0.54 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5681601 | 0.92 | HRH3 (0.56) | ALDH1A1KDM4EBCHEACHEHRH3 | |
| SCHEMBL6057567 | 0.86 | ALDH1A1 (0.63) | ALDH1A1KDM4ESMN1; SMN2BCHEACHE | |
| SCHEMBL14287626 | 0.85 | L3MBTL1 (0.73) | ALDH1A1KDM4ESMN1; SMN2BCHEACHE | |
| SCHEMBL4966805 | 0.85 | TP53 (0.63) | ALDH1A1KDM4ESMN1; SMN2BCHEACHE | |
| SCHEMBL14329438 | 0.84 | THRA (0.53) | BCHETHRATHRBLSS | |
| SCHEMBL5424873 | 0.84 | HRH3 (0.61) | KDM4EBCHEACHEHRH3 | |
| SCHEMBL6630485 | 0.83 | ALDH1A1 (0.60) | ALDH1A1KDM4ESMN1; SMN2BCHEACHE | |
| Hydrochloric Acid SCHEMBL11673412 | 0.83 | HRH3 (0.60) | KDM4EBCHEACHEHRH3 | |
| SCHEMBL321662 | 0.83 | THRA (0.64) | BCHEACHETHRATHRBGAA | |
| SCHEMBL162987 | 0.82 | TP53 (0.64) | ALDH1A1SMN1; SMN2GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9708281-B2 | Process for preparation of dronedarone by the use of dibutylaminopropanol reagent | SANOFI (FR) | 2017-07-18 | — | — | US | disclosed |
| US-9701654-B2 | Process for preparation of dronedarone by removal of hydroxyl group | SANOFI (FR) | 2017-07-11 | — | — | US | disclosed |
| US-9611242-B2 | Process for preparation of dronedarone by N-butylation | SANOFI (FR) | 2017-04-04 | — | — | US | disclosed |
| US-20160075674-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP | SANOFI (FR) | 2016-03-17 | — | — | US | disclosed |
| US-20160075673-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY THE USE OF DIBUTYLAMINOPROPANOL REAGENT | SANOFI (FR) | 2016-03-17 | — | — | US | disclosed |
| US-20160009679-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY N-BUTYLATION | SANOFI (FR) | 2016-01-14 | — | — | US | disclosed |
| US-9221778-B2 | Process for preparation of dronedarone by removal of hydroxyl group | SANOFI (FR) | 2015-12-29 | — | — | US | disclosed |
| US-9221777-B2 | Process for preparation of dronedarone by the use of dibutylaminopropanol reagent | SANOFI (FR) | 2015-12-29 | — | — | US | disclosed |
| US-9193703-B2 | Process for preparation of dronedarone by mesylation | SANOFI (FR) | 2015-11-24 | — | — | US | disclosed |
| US-9174959-B2 | Process for preparation of dronedarone by N-butylation | SANOFI (FR) | 2015-11-03 | — | — | US | disclosed |
| US-9024046-B2 | Reductive amination process for preparation of dronedarone using amine intermediary compound | SANOFI (FR) | 2015-05-05 | — | — | US | disclosed |
| US-20150005515-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP | SANOFI (FR) | 2015-01-01 | — | — | US | disclosed |
| US-20140114081-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY N-BUTYLATION | SANOFI (FR) | 2014-04-24 | — | — | US | disclosed |
| US-20140081035-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY MESYLATION | SANOFI (FR) | 2014-03-20 | — | — | US | disclosed |
| US-20140018554-A1 | REDUCTIVE AMINATION PROCESS FOR PREPARATION OF DRONEDARONE USING AMINE INTERMEDIARY COMPOUND | SANOFI (FR) | 2014-01-16 | — | — | US | disclosed |
| US-20080261975-A1 | Tec Kinase Inhibitors | BENTZIEN JOERG MARTIN | 2008-10-23 | — | — | US | disclosed |
| EP-1957491-A2 | PYRROLO (2,3-B) PYRIDINE DERIVATIVES USEFUL AS TEC KINASE INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007058832-A2 | PYRROLO (2, 3-B) PYRIDINE DERIVATIVES USEFUL AS TEC KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140114081-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY N-BUTYLATION | CYP3A43, CYP3A4, CYP2D6 | ALDH1A1 746/4885KDM4E 799/4885SMN1; SMN2 2365/4885 |
| US-20160075674-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP | CYP2C9, CYP3A43, CYP7A1 | ALDH1A1 352/4885KDM4E 594/4885SMN1; SMN2 3883/4885 |
| US-20080261975-A1 | Tec Kinase Inhibitors | TEC, ITK, LCK | ALDH1A1 3858/4885KDM4E 1478/4885SMN1; SMN2 4558/4885 |
| US-20160075673-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY THE USE OF DIBUTYLAMINOPROPANOL REAGENT | DHCR7, CYP3A43, CYP7A1 | ALDH1A1 415/4885KDM4E 1533/4885SMN1; SMN2 4318/4885 |
| US-20140018554-A1 | REDUCTIVE AMINATION PROCESS FOR PREPARATION OF DRONEDARONE USING AMINE INTERMEDIARY COMPOUND | CYP2D6, CYP2B6, CYP11B2 | ALDH1A1 89/4885KDM4E 1145/4885SMN1; SMN2 3756/4885 |
| US-20160009679-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY N-BUTYLATION | CYP3A43, CYP3A4, CYP2D6 | ALDH1A1 746/4885KDM4E 799/4885SMN1; SMN2 2365/4885 |
| US-20150005515-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY REMOVAL OF HYDROXYL GROUP | CYP2C9, DHCR7, CYP3A4 | ALDH1A1 375/4885KDM4E 405/4885SMN1; SMN2 3810/4885 |
| US-20140081035-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY MESYLATION | CYP2B6, CYP2D6, CYP7A1 | ALDH1A1 407/4885KDM4E 1768/4885SMN1; SMN2 2556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.