Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.60 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | BCHE | P06276 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.56 |
| ▸ | THRA | P10827 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.54 |
| ▸ | LSS | P48449 | 1/20 | 0.54 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3018123 | 0.92 | PARP10 (0.62) | ALDH1A1PARP10KDM4EBCHEACHE | |
| SCHEMBL6057567 | 0.86 | ALDH1A1 (0.63) | ALDH1A1KDM4ESMN1; SMN2BCHEACHE | |
| SCHEMBL4966805 | 0.85 | TP53 (0.63) | ALDH1A1KDM4ESMN1; SMN2BCHEACHE | |
| SCHEMBL14287626 | 0.85 | L3MBTL1 (0.73) | ALDH1A1KDM4ESMN1; SMN2BCHEACHE | |
| SCHEMBL5637020 | 0.84 | CACNA1B (0.58) | ALDH1A1KDM4ESMN1; SMN2BCHEACHE | |
| SCHEMBL4968205 | 0.83 | ALDH1A1 (0.60) | ALDH1A1KDM4ESMN1; SMN2BCHEACHE | |
| SCHEMBL15537107 | 0.83 | THRA (0.64) | PARP10BCHEACHETHRATHRB | |
| SCHEMBL8492151 | 0.83 | SERPINE1 (0.55) | ALDH1A1CHEK2BCHEACHEHRH3 | |
| SCHEMBL8492136 | 0.83 | SERPINE1 (0.55) | ALDH1A1CHEK2BCHEACHEHRH3 | |
| SCHEMBL9015014 | 0.83 | SERPINE1 (0.55) | ALDH1A1CHEK2BCHEACHEHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436291-A2 | INDOLIZINES AS KINASE PROTEIN INHIBITORS | Aventis Pharma S.A. (FR) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003024967-A2 | INDOLIZINES AS KINASE PROTEIN INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2003-03-27 | — | — | WO | disclosed |