Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | QDPR | P09417 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 8/20 | 0.45 |
| ▸ | TNKS | O95271 | 3/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.43 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1765234 | 0.91 | QDPR (0.56) | KDM1AMAOBQDPRHTR2CTNKS | |
| Hydrochloric Acid SCHEMBL1764764 | 0.90 | QDPR (0.55) | KDM1AMAOBQDPRHTR2CTNKS | |
| SCHEMBL241200 | 0.86 | SLC18A3 (0.50) | QDPRHTR2CTNKSTNKS2SLC18A3 | |
| Hydrochloric Acid SCHEMBL1765191 | 0.84 | HTR2C (0.48) | QDPRHTR2CTNKSTNKS2SLC18A3 | |
| SCHEMBL16660426 | 0.81 | HTR3A (0.59) | KDM1AMAOBQDPRSLC6A2SLC6A4 | |
| SCHEMBL724585 | 0.81 | HTR3A (0.59) | KDM1AMAOBQDPRSLC6A2SLC6A4 | |
| SCHEMBL4968460 | 0.80 | CCR2 (0.42) | QDPRHTR2C | |
| SCHEMBL29389392 | 0.78 | HTR2A (0.46) | KDM1AMAOBQDPRHTR2CSLC6A2 | |
| SCHEMBL808710 | 0.78 | HTR2A (0.46) | KDM1AMAOBQDPRHTR2CSLC6A2 | |
| SCHEMBL3384000 | 0.77 | SLC18A3 (0.42) | QDPRHTR2CSLC18A3SIGMAR1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963268-A1 | DISUBSTITUTED PHENYLPIPERIDINES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION | Neurosearch Sweden AB (SE) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007065655-A1 | DISUBSTITUTED PHENYLPIPERIDINES AS MODULATORS OF CORTICAL CATECHOLAMINERGIC NEUROTRANSMISSION | NEUROSEARCH SWEDEN AB (SE) | 2007-06-14 | — | — | WO | disclosed |