Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3831699 | 0.82 | KMT2A (0.49) | LMNASLC1A2HPGDMMEOPRK1 | |
| SCHEMBL12799330 | 0.80 | CTSS (0.59) | CTSSCTSK | |
| SCHEMBL2855987 | 0.80 | CA1 (0.52) | CTSSCTSKGRM5TDP1LMNA | |
| SCHEMBL2851881 | 0.78 | CA12 (0.41) | CTSSCTSKGRM5TDP1LMNA | |
| SCHEMBL4971087 | 0.77 | MMP13 (0.43) | LMNAHPGDOPRM1ALDH1A1 | |
| SCHEMBL4966958 | 0.76 | EPHX2 (0.44) | LMNAOPRM1ALDH1A1 | |
| SCHEMBL4969815 | 0.76 | F2 (0.38) | CTSSCTSKGRM5HCRTR1HCRTR2 | |
| SCHEMBL2852749 | 0.73 | HPGD (0.43) | GRM5TDP1LMNASLC1A3SLC1A2 | |
| SCHEMBL8295315 | 0.72 | ERCC1 (0.53) | GRM5TDP1LMNAHDAC8HDAC6 | |
| SCHEMBL2852748 | 0.72 | GRM5 (0.40) | GRM5TDP1LMNASLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963277-A1 | FLUORINATED COMPOUNDS | NPS PHARMACEUTICALS, INC. (US) | 2008-09-03 | — | — | EP | claimed |
| WO-2007076306-A1 | FLUORINATED COMPOUNDS | NPS PHARMACEUTICALS, INC. (US) | 2007-07-05 | — | — | WO | claimed |