Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | GFER | P55789 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.57 |
| ▸ | RELA | Q04206 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11207412 | 0.88 | DYRK1A (0.72) | KDM4EALDH1A1SMN1; SMN2TDP1NPC1 | |
| SCHEMBL11205987 | 0.88 | NPC1 (0.62) | KDM4EALDH1A1SMN1; SMN2TDP1NPC1 | |
| SCHEMBL13853337 | 0.84 | HSD17B10 (0.61) | KDM4EALDH1A1SMN1; SMN2TDP1NPC1 | |
| SCHEMBL4746038 | 0.84 | LDHA (0.61) | KDM4EALDH1A1SMN1; SMN2TDP1NPC1 | |
| SCHEMBL24729341 | 0.82 | HSD17B10 (0.73) | KDM4EALDH1A1SMN1; SMN2TDP1NPC1 | |
| SCHEMBL29947460 | 0.82 | HSD17B10 (0.73) | KDM4EALDH1A1SMN1; SMN2TDP1NPC1 | |
| SCHEMBL6058154 | 0.82 | DYRK1A (0.77) | ALDH1A1SMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL19921646 | 0.81 | HSD17B10 (0.60) | KDM4EALDH1A1SMN1; SMN2TDP1NPC1 | |
| SCHEMBL31087734 | 0.81 | SMN1; SMN2 (0.54) | KDM4EALDH1A1SMN1; SMN2TDP1NPC1 | |
| SCHEMBL23628970 | 0.81 | SMN1; SMN2 (0.54) | KDM4EALDH1A1SMN1; SMN2TDP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008118790-A1 | DIHYDROINDAZOLE COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2008-10-02 | — | — | WO | disclosed |
| US-20080234327-A1 | DIHYDROINDAZOLE COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2008-09-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080234327-A1 | DIHYDROINDAZOLE COMPOUNDS USEFUL IN TREATING IRON DISORDERS | FECH, SLC40A1, HAMP | KDM4E 2577/4885ALDH1A1 514/4885SMN1; SMN2 1839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.