Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.42 |
| ▸ | SCD5 | Q86SK9 | 6/20 | 0.41 |
| ▸ | SCD | O00767 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 4/20 | 0.41 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4970437 | 0.91 | SCD5 (0.49) | SCD5SCDHTR2CNPC1MAPT | |
| SCHEMBL5660759 | 0.83 | SPR (0.46) | SPRNAMPTHSD11B1SCD5SCD | |
| SCHEMBL4974911 | 0.81 | HTR2C (0.64) | SPRNAMPTHSD11B1SCD5SCD | |
| SCHEMBL4970419 | 0.79 | HTR2C (0.46) | HTR2CNPC1RAB9A | |
| SCHEMBL4971657 | 0.79 | HTR2C (0.44) | HTR2C | |
| SCHEMBL4973462 | 0.79 | HTR2C (0.60) | HTR2CNPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4974086 | 0.79 | HTR2C (0.60) | HTR2CNPC1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL4971490 | 0.77 | HTR2C (0.42) | SPRHSD11B1SCD5SCDHTR2C | |
| SCHEMBL4973107 | 0.73 | APLNR (0.48) | SPRNAMPTAPLNRPIM1PIM3 | |
| SCHEMBL4973944 | 0.73 | HPGD (0.42) | HTR2CNPC1MAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979335-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007082808-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-26 | — | — | WO | disclosed |